MOX Nanosensors to Detect Colorectal Cancer Relapses from Patient’s Blood at Three Years Follow-Up, and Gender Correlation
Colorectal cancer represents 10% of all the annual tumors diagnosed worldwide, being often not timely diagnosed, because its symptoms are typically lacking or very mild. Therefore, it is crucial to develop and validate innovative low-invasive techniques to detect it before becoming intractable. To t...
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| Format: | Article |
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MDPI AG
2025-01-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/15/1/56 |
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| author | Michele Astolfi Giulia Zonta Cesare Malagù Gabriele Anania Giorgio Rispoli |
| author_facet | Michele Astolfi Giulia Zonta Cesare Malagù Gabriele Anania Giorgio Rispoli |
| author_sort | Michele Astolfi |
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| description | Colorectal cancer represents 10% of all the annual tumors diagnosed worldwide, being often not timely diagnosed, because its symptoms are typically lacking or very mild. Therefore, it is crucial to develop and validate innovative low-invasive techniques to detect it before becoming intractable. To this aim, a device equipped with nanostructured gas sensors has been employed to detect the airborne molecules of blood samples collected from healthy subjects, and from colorectal cancer affected patients at different stages of their pre- and post-surgery therapeutic path. Data was scrutinized by using statistical standard techniques to highlight their statistical differences, and through principal component analysis and support vector machine to classify them. The device was able to readily distinguish between the pre-surgery blood samples (i.e., taken when the patient had cancer), and the ones up to three years post-surgery (i.e., following the tumor removal) or the ones from healthy subjects. Finally, the correlation of the sensor responses with the patient/healthy subject’s gender was investigated, resulting negligible. These results pave the path toward a clinical validation of this device to monitor the patient’s health status by detecting possible relapses, to parallel to clinical follow-up protocols. |
| format | Article |
| id | doaj-art-ea994cea477e4d6ba3dae8f6e7a3e40f |
| institution | Kabale University |
| issn | 2079-6374 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Biosensors |
| spelling | doaj-art-ea994cea477e4d6ba3dae8f6e7a3e40f2025-01-24T13:25:35ZengMDPI AGBiosensors2079-63742025-01-011515610.3390/bios15010056MOX Nanosensors to Detect Colorectal Cancer Relapses from Patient’s Blood at Three Years Follow-Up, and Gender CorrelationMichele Astolfi0Giulia Zonta1Cesare Malagù2Gabriele Anania3Giorgio Rispoli4Department of Neuroscience and Rehabilitation, University of Ferrara, 44121 Ferrara, ItalySCENT S.r.l., Via Quadrifoglio 11, 44124 Ferrara, ItalySCENT S.r.l., Via Quadrifoglio 11, 44124 Ferrara, ItalyDepartment of Medical Sciences, University of Ferrara, 44121 Ferrara, ItalyDepartment of Neuroscience and Rehabilitation, University of Ferrara, 44121 Ferrara, ItalyColorectal cancer represents 10% of all the annual tumors diagnosed worldwide, being often not timely diagnosed, because its symptoms are typically lacking or very mild. Therefore, it is crucial to develop and validate innovative low-invasive techniques to detect it before becoming intractable. To this aim, a device equipped with nanostructured gas sensors has been employed to detect the airborne molecules of blood samples collected from healthy subjects, and from colorectal cancer affected patients at different stages of their pre- and post-surgery therapeutic path. Data was scrutinized by using statistical standard techniques to highlight their statistical differences, and through principal component analysis and support vector machine to classify them. The device was able to readily distinguish between the pre-surgery blood samples (i.e., taken when the patient had cancer), and the ones up to three years post-surgery (i.e., following the tumor removal) or the ones from healthy subjects. Finally, the correlation of the sensor responses with the patient/healthy subject’s gender was investigated, resulting negligible. These results pave the path toward a clinical validation of this device to monitor the patient’s health status by detecting possible relapses, to parallel to clinical follow-up protocols.https://www.mdpi.com/2079-6374/15/1/56chemoresistivitygas sensornanotechnologyVOCsbloodcolorectal cancer |
| spellingShingle | Michele Astolfi Giulia Zonta Cesare Malagù Gabriele Anania Giorgio Rispoli MOX Nanosensors to Detect Colorectal Cancer Relapses from Patient’s Blood at Three Years Follow-Up, and Gender Correlation Biosensors chemoresistivity gas sensor nanotechnology VOCs blood colorectal cancer |
| title | MOX Nanosensors to Detect Colorectal Cancer Relapses from Patient’s Blood at Three Years Follow-Up, and Gender Correlation |
| title_full | MOX Nanosensors to Detect Colorectal Cancer Relapses from Patient’s Blood at Three Years Follow-Up, and Gender Correlation |
| title_fullStr | MOX Nanosensors to Detect Colorectal Cancer Relapses from Patient’s Blood at Three Years Follow-Up, and Gender Correlation |
| title_full_unstemmed | MOX Nanosensors to Detect Colorectal Cancer Relapses from Patient’s Blood at Three Years Follow-Up, and Gender Correlation |
| title_short | MOX Nanosensors to Detect Colorectal Cancer Relapses from Patient’s Blood at Three Years Follow-Up, and Gender Correlation |
| title_sort | mox nanosensors to detect colorectal cancer relapses from patient s blood at three years follow up and gender correlation |
| topic | chemoresistivity gas sensor nanotechnology VOCs blood colorectal cancer |
| url | https://www.mdpi.com/2079-6374/15/1/56 |
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