Probiotics and Prebiotics: Role in Prevention of Nosocomial Sepsis in Preterm Infants
Nosocomial sepsis is associated with increased mortality and morbidity including neurodevelopmental impairment and prolonged hospital stay. Prevention of sepsis especially in the preterm infants in the neonatal intensive care unit remains a major challenge. The gastrointestinal tract is an important...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2013/874726 |
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| author | Vrinda Nair Amuchou S. Soraisham |
| author_facet | Vrinda Nair Amuchou S. Soraisham |
| author_sort | Vrinda Nair |
| collection | DOAJ |
| description | Nosocomial sepsis is associated with increased mortality and morbidity including neurodevelopmental impairment and prolonged hospital stay. Prevention of sepsis especially in the preterm infants in the neonatal intensive care unit remains a major challenge. The gastrointestinal tract is an important source of potential pathogens causing nosocomial sepsis as the immature intestinal epithelium can permit translocation of bacteria and yeast. The intestinal tract and its microflora play an important role in the immunity. Altering the gut microflora has been extensively studied for immunomodulation in preterm infants. Probiotics are live microorganisms which when administered in adequate amounts confer a health benefit on the host. Probiotics have been used for prevention and treatment of various medical conditions in children and adults. Studies on probiotics in premature infants have focused on normalizing intestinal flora, improvement in feeding intolerance, prevention of necrotizing enterocolitis and sepsis. In this paper, we discuss the intestinal bacterial colonization pattern; the rational for probiotics and prebiotic therapy with special focus on the prevention of nosocomial sepsis in preterm infants. |
| format | Article |
| id | doaj-art-ea921414a0ff47f680ff788b5d9a4935 |
| institution | Kabale University |
| issn | 1687-9740 1687-9759 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj-art-ea921414a0ff47f680ff788b5d9a49352025-02-03T06:11:35ZengWileyInternational Journal of Pediatrics1687-97401687-97592013-01-01201310.1155/2013/874726874726Probiotics and Prebiotics: Role in Prevention of Nosocomial Sepsis in Preterm InfantsVrinda Nair0Amuchou S. Soraisham1Section of Neonatology, Department of Pediatrics, University of Calgary, Calgary, AB, T1N 1N4, CanadaSection of Neonatology, Department of Pediatrics, University of Calgary, Calgary, AB, T1N 1N4, CanadaNosocomial sepsis is associated with increased mortality and morbidity including neurodevelopmental impairment and prolonged hospital stay. Prevention of sepsis especially in the preterm infants in the neonatal intensive care unit remains a major challenge. The gastrointestinal tract is an important source of potential pathogens causing nosocomial sepsis as the immature intestinal epithelium can permit translocation of bacteria and yeast. The intestinal tract and its microflora play an important role in the immunity. Altering the gut microflora has been extensively studied for immunomodulation in preterm infants. Probiotics are live microorganisms which when administered in adequate amounts confer a health benefit on the host. Probiotics have been used for prevention and treatment of various medical conditions in children and adults. Studies on probiotics in premature infants have focused on normalizing intestinal flora, improvement in feeding intolerance, prevention of necrotizing enterocolitis and sepsis. In this paper, we discuss the intestinal bacterial colonization pattern; the rational for probiotics and prebiotic therapy with special focus on the prevention of nosocomial sepsis in preterm infants.http://dx.doi.org/10.1155/2013/874726 |
| spellingShingle | Vrinda Nair Amuchou S. Soraisham Probiotics and Prebiotics: Role in Prevention of Nosocomial Sepsis in Preterm Infants International Journal of Pediatrics |
| title | Probiotics and Prebiotics: Role in Prevention of Nosocomial Sepsis in Preterm Infants |
| title_full | Probiotics and Prebiotics: Role in Prevention of Nosocomial Sepsis in Preterm Infants |
| title_fullStr | Probiotics and Prebiotics: Role in Prevention of Nosocomial Sepsis in Preterm Infants |
| title_full_unstemmed | Probiotics and Prebiotics: Role in Prevention of Nosocomial Sepsis in Preterm Infants |
| title_short | Probiotics and Prebiotics: Role in Prevention of Nosocomial Sepsis in Preterm Infants |
| title_sort | probiotics and prebiotics role in prevention of nosocomial sepsis in preterm infants |
| url | http://dx.doi.org/10.1155/2013/874726 |
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