Unlocking tumor barrier: annexin A2-mediated transcytosis boosts drug delivery in pancreatic and breast tumors

Abstract The efficacy of many cancer nanocarriers has traditionally been attributed to enlarged tumor vasculature fenestrations, giving rise to the concept of the enhanced permeability and retention (EPR) effect. However, emerging evidence suggests that active biological processes, such as transcyto...

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Bibliographic Details
Main Authors: Yanyan Liu, Qikai Wang, Zhenhan Feng, Mengmeng Qin, Zhenyu Zhang, Jinhong Jiang, Tongxiang Ren, Xiangsheng Liu, C. Jeffrey Brinker, Yuliang Zhao, Huan Meng
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61434-5
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