Analysis of diabetes mellitus screening method based on electrical properties of cells using dielectric method
Diabetes mellitus is one of the most dangerous diseases in the world because every year, people with diabetes always increase. Methods development for diagnosing diabetes mellitus was carried out to obtain better results. This study aims to analyze diabetes mellitus screening methods based on the el...
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EDP Sciences
2025-01-01
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| Series: | BIO Web of Conferences |
| Online Access: | https://www.bio-conferences.org/articles/bioconf/pdf/2025/05/bioconf_icgrc2025_02006.pdf |
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| author | Faisal Muhammad Juswono Unggul Pundjung Santoso Didik Rahadi Widodo Chomsin Sulistya |
| author_facet | Faisal Muhammad Juswono Unggul Pundjung Santoso Didik Rahadi Widodo Chomsin Sulistya |
| author_sort | Faisal Muhammad |
| collection | DOAJ |
| description | Diabetes mellitus is one of the most dangerous diseases in the world because every year, people with diabetes always increase. Methods development for diagnosing diabetes mellitus was carried out to obtain better results. This study aims to analyze diabetes mellitus screening methods based on the electrical properties of cells using the dielectric method. This study used 90 mice (Mus musculus) as experimental subjects. Mice were divided into six groups: one group without streptozotocin injection (Control) and five groups injected with streptozotocin. Streptozotocin doses given were 10 mg/KgBW (P1), 15 mg/KgBW (P2), 20 mg/KgBW (P3), 25 mg/KgBW (P4), and 30 mg/KgBW (P5). Mice that had experienced hyperglycemia had their dielectric constant measured using electrical impedance spectroscopy (EIS), and changes in cell morphology were observed using a binocular microscope. The results showed that the dielectric constant value of the control group was 35000, the pre-diabetes group (P1 and P2) was 35000 to 20000, while the acute diabetes mellitus group (P3, P4, and P5) was below 20000. The results of histopathological observations identified five types of specific cell damage, namely microcytes (9%), hypochromic (11%), burr cells (20%), schistocytes (20%), and macrocytic hypochromic (40%). Electrical properties of cells in the form of dielectric constants can show area dispersion at different levels of diabetes. The results of dielectric constant measurements correlate with the histopathological picture. Percentage of accumulated damage is 32% (P1); 40% (P2); 55% (P3); 65% (P4); and 74% (P5). The dielectric method can be used as an alternative method for screening diabetes mellitus based on the electrical properties of cells. |
| format | Article |
| id | doaj-art-ea4c349fb52f4b3697d4a3550c531ffc |
| institution | Kabale University |
| issn | 2117-4458 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | BIO Web of Conferences |
| spelling | doaj-art-ea4c349fb52f4b3697d4a3550c531ffc2025-02-05T10:43:07ZengEDP SciencesBIO Web of Conferences2117-44582025-01-011540200610.1051/bioconf/202515402006bioconf_icgrc2025_02006Analysis of diabetes mellitus screening method based on electrical properties of cells using dielectric methodFaisal Muhammad0Juswono Unggul Pundjung1Santoso Didik Rahadi2Widodo Chomsin Sulistya3Department of Physic, Brawijaya UniversityDepartment of Physic, Brawijaya UniversityDepartment of Physic, Brawijaya UniversityDepartment of Physic, Brawijaya UniversityDiabetes mellitus is one of the most dangerous diseases in the world because every year, people with diabetes always increase. Methods development for diagnosing diabetes mellitus was carried out to obtain better results. This study aims to analyze diabetes mellitus screening methods based on the electrical properties of cells using the dielectric method. This study used 90 mice (Mus musculus) as experimental subjects. Mice were divided into six groups: one group without streptozotocin injection (Control) and five groups injected with streptozotocin. Streptozotocin doses given were 10 mg/KgBW (P1), 15 mg/KgBW (P2), 20 mg/KgBW (P3), 25 mg/KgBW (P4), and 30 mg/KgBW (P5). Mice that had experienced hyperglycemia had their dielectric constant measured using electrical impedance spectroscopy (EIS), and changes in cell morphology were observed using a binocular microscope. The results showed that the dielectric constant value of the control group was 35000, the pre-diabetes group (P1 and P2) was 35000 to 20000, while the acute diabetes mellitus group (P3, P4, and P5) was below 20000. The results of histopathological observations identified five types of specific cell damage, namely microcytes (9%), hypochromic (11%), burr cells (20%), schistocytes (20%), and macrocytic hypochromic (40%). Electrical properties of cells in the form of dielectric constants can show area dispersion at different levels of diabetes. The results of dielectric constant measurements correlate with the histopathological picture. Percentage of accumulated damage is 32% (P1); 40% (P2); 55% (P3); 65% (P4); and 74% (P5). The dielectric method can be used as an alternative method for screening diabetes mellitus based on the electrical properties of cells.https://www.bio-conferences.org/articles/bioconf/pdf/2025/05/bioconf_icgrc2025_02006.pdf |
| spellingShingle | Faisal Muhammad Juswono Unggul Pundjung Santoso Didik Rahadi Widodo Chomsin Sulistya Analysis of diabetes mellitus screening method based on electrical properties of cells using dielectric method BIO Web of Conferences |
| title | Analysis of diabetes mellitus screening method based on electrical properties of cells using dielectric method |
| title_full | Analysis of diabetes mellitus screening method based on electrical properties of cells using dielectric method |
| title_fullStr | Analysis of diabetes mellitus screening method based on electrical properties of cells using dielectric method |
| title_full_unstemmed | Analysis of diabetes mellitus screening method based on electrical properties of cells using dielectric method |
| title_short | Analysis of diabetes mellitus screening method based on electrical properties of cells using dielectric method |
| title_sort | analysis of diabetes mellitus screening method based on electrical properties of cells using dielectric method |
| url | https://www.bio-conferences.org/articles/bioconf/pdf/2025/05/bioconf_icgrc2025_02006.pdf |
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