High afterload rather than myocardial fibrosis predicts reduced ejection fraction in severe aortic stenosis with afterload mismatch

Background Afterload mismatch (AM) refers to high-gradient (mean gradient ≥40 mm Hg) severe aortic stenosis (AS) with reduced left ventricular ejection fraction (LVEF <50%) that is hypothesised to arise from mechanisms other than true contractile impairment. The extent, pattern and functional...

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Bibliographic Details
Main Authors: Anton Doubell, Philip Herbst, Megan Rian Rajah
Format: Article
Language:English
Published: BMJ Publishing Group 2025-05-01
Series:Open Heart
Online Access:https://openheart.bmj.com/content/12/1/e003345.full
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