Headache in radiologically isolated syndrome: a hint toward imminent conversion: a case report
Abstract Background Headaches are more prevalent in patients with multiple sclerosis compared with the general population. However, headaches are still considered a rare symptom of multiple sclerosis, especially when they appear as an initial symptom. The occurrence of a headache as a symptom of rad...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Journal of Medical Case Reports |
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| Online Access: | https://doi.org/10.1186/s13256-025-05023-6 |
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| author | Masoud Etemadifar Hasan Kaveyee Parto Zohrabi Amir Mohammad Jozaie Mehri Salari Yasin ebne-ali-heydari |
| author_facet | Masoud Etemadifar Hasan Kaveyee Parto Zohrabi Amir Mohammad Jozaie Mehri Salari Yasin ebne-ali-heydari |
| author_sort | Masoud Etemadifar |
| collection | DOAJ |
| description | Abstract Background Headaches are more prevalent in patients with multiple sclerosis compared with the general population. However, headaches are still considered a rare symptom of multiple sclerosis, especially when they appear as an initial symptom. The occurrence of a headache as a symptom of radiologically isolated syndrome (RIS) is uncommon, and it can significantly increase the likelihood of developing multiple sclerosis. Case presentation We report the case of a 36-year-old Iranian woman experiencing severe unilateral headaches without other multiple sclerosis symptoms. Despite normal physical and laboratory exams, cerebrospinal fluid analysis showed positive oligoclonal bands. Magnetic resonance imaging (MRI) revealed multiple demyelinating plaques consistent with RIS. She was treated with dimethyl fumarate. Subsequent MRI confirmed multiple sclerosis by showing new gadolinium-enhanced lesions. After 3 months of dimethyl fumarate treatment, her headache intensity decreased, and she remained otherwise symptom free. Written informed consent was obtained from the patient. Conclusion Effectively managing headaches in patients with RIS is a challenge for clinicians to improve their quality of life and delay the progression of multiple sclerosis. |
| format | Article |
| id | doaj-art-e9fc8e2cbbbd4467b0d38213d52cf143 |
| institution | Kabale University |
| issn | 1752-1947 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj-art-e9fc8e2cbbbd4467b0d38213d52cf1432025-01-19T12:25:08ZengBMCJournal of Medical Case Reports1752-19472025-01-011911410.1186/s13256-025-05023-6Headache in radiologically isolated syndrome: a hint toward imminent conversion: a case reportMasoud Etemadifar0Hasan Kaveyee1Parto Zohrabi2Amir Mohammad Jozaie3Mehri Salari4Yasin ebne-ali-heydari5School of Medicine, Isfahan University of Medical SciencesSchool of Medicine, Isfahan University of Medical SciencesSchool of Medicine, Isfahan University of Medical SciencesSchool of Medicine, Isfahan University of Medical SciencesFunctional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical SciencesSchool of Medicine, Isfahan University of Medical SciencesAbstract Background Headaches are more prevalent in patients with multiple sclerosis compared with the general population. However, headaches are still considered a rare symptom of multiple sclerosis, especially when they appear as an initial symptom. The occurrence of a headache as a symptom of radiologically isolated syndrome (RIS) is uncommon, and it can significantly increase the likelihood of developing multiple sclerosis. Case presentation We report the case of a 36-year-old Iranian woman experiencing severe unilateral headaches without other multiple sclerosis symptoms. Despite normal physical and laboratory exams, cerebrospinal fluid analysis showed positive oligoclonal bands. Magnetic resonance imaging (MRI) revealed multiple demyelinating plaques consistent with RIS. She was treated with dimethyl fumarate. Subsequent MRI confirmed multiple sclerosis by showing new gadolinium-enhanced lesions. After 3 months of dimethyl fumarate treatment, her headache intensity decreased, and she remained otherwise symptom free. Written informed consent was obtained from the patient. Conclusion Effectively managing headaches in patients with RIS is a challenge for clinicians to improve their quality of life and delay the progression of multiple sclerosis.https://doi.org/10.1186/s13256-025-05023-6HeadacheRadiologically isolated syndromeMultiple sclerosis |
| spellingShingle | Masoud Etemadifar Hasan Kaveyee Parto Zohrabi Amir Mohammad Jozaie Mehri Salari Yasin ebne-ali-heydari Headache in radiologically isolated syndrome: a hint toward imminent conversion: a case report Journal of Medical Case Reports Headache Radiologically isolated syndrome Multiple sclerosis |
| title | Headache in radiologically isolated syndrome: a hint toward imminent conversion: a case report |
| title_full | Headache in radiologically isolated syndrome: a hint toward imminent conversion: a case report |
| title_fullStr | Headache in radiologically isolated syndrome: a hint toward imminent conversion: a case report |
| title_full_unstemmed | Headache in radiologically isolated syndrome: a hint toward imminent conversion: a case report |
| title_short | Headache in radiologically isolated syndrome: a hint toward imminent conversion: a case report |
| title_sort | headache in radiologically isolated syndrome a hint toward imminent conversion a case report |
| topic | Headache Radiologically isolated syndrome Multiple sclerosis |
| url | https://doi.org/10.1186/s13256-025-05023-6 |
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