Transcriptomic and functional characterization of megakaryocytic-derived platelet-like particles: impaired aggregation and prominent anti-tumor effects

Transcriptomic and functional characterization of megakaryocytic-derived platelet-like particles: impaired aggregation and prominent anti-tumor effects

Platelet-like particles (PLPs), derived from megakaryocytic cell lines MEG-01 and K-562, are widely used as a surrogate to study platelet formation and function. We demonstrate by RNA-Seq that PLPs are transcriptionally distinct from platelets. Expression of key genes in signaling pathways promoting...

Full description

Saved in:
Bibliographic Details
Main Authors: Kaitlin Garofano, Vera Mariani, Kameron Rashid, Sumanun Suwunnakorn, Alfateh Sidahmed, Anelia Horvath, Sanjay B. Maggirwar, Travis J. O’Brien, Minoli A. Perera, Michael Whalen, Norman H. Lee
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Platelets
Subjects:
Apoptosis
cancer biology
cell invasion
functional genomics
MDA-PCa-2b cells
platelet
Online Access:https://www.tandfonline.com/doi/10.1080/09537104.2024.2449344
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.tandfonline.com/doi/10.1080/09537104.2024.2449344

Similar Items