Elucidating the structural dynamics induced by active site mutations in 3C protease of foot-and-mouth disease virus.

The viral replication of foot-and-mouth disease virus (FMDV) and other picornaviruses primarily depends on the successful processing of a polyprotein precursor by the enzyme 3C protease (3Cpro) at specific sites. The crucial role of 3Cpro in viral replication and pathogenesis makes it a potential ta...

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Bibliographic Details
Main Authors: Sthitaprajna Sahoo, Hak-Kyo Lee, Donghyun Shin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0321079
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