Diabetic Nephropathy Induced by Increased Ace Gene Dosage Is Associated with High Renal Levels of Angiotensin (1–7) and Bradykinin
Population studies have shown an association between diabetic nephropathy (DN) and insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene (ACE in humans, Ace in mice). The aim was to evaluate the modulation of Ace copies number and diabetes mellitus (DM) on renal RAS...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2015/674047 |
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| author | Nádia Bertoncello Roseli Peres Moreira Danielle Yuri Arita Danielle S. Aragão Ingrid Kazue Mizuno Watanabe Patricia S. Dantas Ralmony Santos Rodolfo Mattar-Rosa Rodrigo Yokota Tatiana Sousa Cunha Dulce Elena Casarini |
| author_facet | Nádia Bertoncello Roseli Peres Moreira Danielle Yuri Arita Danielle S. Aragão Ingrid Kazue Mizuno Watanabe Patricia S. Dantas Ralmony Santos Rodolfo Mattar-Rosa Rodrigo Yokota Tatiana Sousa Cunha Dulce Elena Casarini |
| author_sort | Nádia Bertoncello |
| collection | DOAJ |
| description | Population studies have shown an association between diabetic nephropathy (DN) and insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene (ACE in humans, Ace in mice). The aim was to evaluate the modulation of Ace copies number and diabetes mellitus (DM) on renal RAS and correlate it with indicators of kidney function. Increased number of copies of the Ace gene, associated with DM, induces renal dysfunction. The susceptibility to the development of DN in 3 copies of animals is associated with an imbalance in activity of RAS enzymes leading to increased synthesis of Ang II and Ang-(1–7). Increased concentration of renal Ang-(1–7) appears to potentiate the deleterious effects triggered by Ang II on kidney structure and function. Results also show increased bradykinin concentration in 3 copies diabetic group. Taken together, results indicate that the deleterious effects described in 3 copies diabetic group are, at least in part, due to a combination of factors not usually described in the literature. Thus, the data presented here show up innovative and contribute to understanding the complex mechanisms involved in the development of DN, in order to optimize the treatment of patients with this complication. |
| format | Article |
| id | doaj-art-e9d7e976b30340e4a7c21a41436dc0c9 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-e9d7e976b30340e4a7c21a41436dc0c92025-02-03T06:44:47ZengWileyJournal of Diabetes Research2314-67452314-67532015-01-01201510.1155/2015/674047674047Diabetic Nephropathy Induced by Increased Ace Gene Dosage Is Associated with High Renal Levels of Angiotensin (1–7) and BradykininNádia Bertoncello0Roseli Peres Moreira1Danielle Yuri Arita2Danielle S. Aragão3Ingrid Kazue Mizuno Watanabe4Patricia S. Dantas5Ralmony Santos6Rodolfo Mattar-Rosa7Rodrigo Yokota8Tatiana Sousa Cunha9Dulce Elena Casarini10Nephrology Division, Department of Medicine, Federal University of São Paulo, Rua Botucatu 740, Vila Clementino, 04023-900 São Paulo, SP, BrazilNephrology Division, Department of Medicine, Federal University of São Paulo, Rua Botucatu 740, Vila Clementino, 04023-900 São Paulo, SP, BrazilNephrology Division, Department of Medicine, Federal University of São Paulo, Rua Botucatu 740, Vila Clementino, 04023-900 São Paulo, SP, BrazilNephrology Division, Department of Medicine, Federal University of São Paulo, Rua Botucatu 740, Vila Clementino, 04023-900 São Paulo, SP, BrazilNephrology Division, Department of Medicine, Federal University of São Paulo, Rua Botucatu 740, Vila Clementino, 04023-900 São Paulo, SP, BrazilNephrology Division, Department of Medicine, Federal University of São Paulo, Rua Botucatu 740, Vila Clementino, 04023-900 São Paulo, SP, BrazilNephrology Division, Department of Medicine, Federal University of São Paulo, Rua Botucatu 740, Vila Clementino, 04023-900 São Paulo, SP, BrazilNephrology Division, Department of Medicine, Federal University of São Paulo, Rua Botucatu 740, Vila Clementino, 04023-900 São Paulo, SP, BrazilNephrology Division, Department of Medicine, Federal University of São Paulo, Rua Botucatu 740, Vila Clementino, 04023-900 São Paulo, SP, BrazilScience and Technology Department, Federal University of São Paulo, São José dos Campos, SP, BrazilNephrology Division, Department of Medicine, Federal University of São Paulo, Rua Botucatu 740, Vila Clementino, 04023-900 São Paulo, SP, BrazilPopulation studies have shown an association between diabetic nephropathy (DN) and insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene (ACE in humans, Ace in mice). The aim was to evaluate the modulation of Ace copies number and diabetes mellitus (DM) on renal RAS and correlate it with indicators of kidney function. Increased number of copies of the Ace gene, associated with DM, induces renal dysfunction. The susceptibility to the development of DN in 3 copies of animals is associated with an imbalance in activity of RAS enzymes leading to increased synthesis of Ang II and Ang-(1–7). Increased concentration of renal Ang-(1–7) appears to potentiate the deleterious effects triggered by Ang II on kidney structure and function. Results also show increased bradykinin concentration in 3 copies diabetic group. Taken together, results indicate that the deleterious effects described in 3 copies diabetic group are, at least in part, due to a combination of factors not usually described in the literature. Thus, the data presented here show up innovative and contribute to understanding the complex mechanisms involved in the development of DN, in order to optimize the treatment of patients with this complication.http://dx.doi.org/10.1155/2015/674047 |
| spellingShingle | Nádia Bertoncello Roseli Peres Moreira Danielle Yuri Arita Danielle S. Aragão Ingrid Kazue Mizuno Watanabe Patricia S. Dantas Ralmony Santos Rodolfo Mattar-Rosa Rodrigo Yokota Tatiana Sousa Cunha Dulce Elena Casarini Diabetic Nephropathy Induced by Increased Ace Gene Dosage Is Associated with High Renal Levels of Angiotensin (1–7) and Bradykinin Journal of Diabetes Research |
| title | Diabetic Nephropathy Induced by Increased Ace Gene Dosage Is Associated with High Renal Levels of Angiotensin (1–7) and Bradykinin |
| title_full | Diabetic Nephropathy Induced by Increased Ace Gene Dosage Is Associated with High Renal Levels of Angiotensin (1–7) and Bradykinin |
| title_fullStr | Diabetic Nephropathy Induced by Increased Ace Gene Dosage Is Associated with High Renal Levels of Angiotensin (1–7) and Bradykinin |
| title_full_unstemmed | Diabetic Nephropathy Induced by Increased Ace Gene Dosage Is Associated with High Renal Levels of Angiotensin (1–7) and Bradykinin |
| title_short | Diabetic Nephropathy Induced by Increased Ace Gene Dosage Is Associated with High Renal Levels of Angiotensin (1–7) and Bradykinin |
| title_sort | diabetic nephropathy induced by increased ace gene dosage is associated with high renal levels of angiotensin 1 7 and bradykinin |
| url | http://dx.doi.org/10.1155/2015/674047 |
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