Optimizing CAR-T cell therapy for solid tumors: current challenges and potential strategies

Optimizing CAR-T cell therapy for solid tumors: current challenges and potential strategies

Abstract Chimeric antigen receptor (CAR)-T cell therapy demonstrates substantial efficacy in various hematological malignancies. However, its application in solid tumors is still limited. Clinical studies report suboptimal outcomes such as reduced cytotoxicity of CAR-T cells and tumor evasion, under...

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Bibliographic Details
Main Authors: Kexin Ai, Bowen Liu, Xiaomei Chen, Chuxin Huang, liping Yang, Weiya Zhang, Jianyu Weng, Xin Du, Kongming Wu, Peilong Lai
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Journal of Hematology & Oncology
Subjects:
CAR-T cell therapy
Solid tumors
Challenges of cytotoxicity
Restriction in application
Novel technologies
Online Access:https://doi.org/10.1186/s13045-024-01625-7
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https://doi.org/10.1186/s13045-024-01625-7

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