Novel Biphasic Role of Resolvin D1 on Expression of Cyclooxygenase-2 in Lipopolysaccharide-Stimulated Lung Fibroblasts Is Partly through PI3K/AKT and ERK2 Pathways

Fibroblasts, far frombeing merely bystander cells, are known to play a specific role in inflammation resolution after an acute injury. As the endogenous “braking signal,” resolvins possess potent anti-inflammatory and proresolution actions. We demonstrated that the expression of COX-2 protein was si...

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Bibliographic Details
Main Authors: Derong Wu, Shengxing Zheng, Wenjuan Li, Li Yang, Yongjian Liu, Xia Zheng, Yi Yang, Liangmin Yang, Qian Wang, Fang Gao Smith, Shengwei Jin
Format: Article
Language:English
Published: Wiley 2013-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2013/964012
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