Inhibition RIP1 prevents acute liver failure by suppressing hepatic apoptosis and attenuating the secretion of TNF-α from macrophages

Inhibition RIP1 prevents acute liver failure by suppressing hepatic apoptosis and attenuating the secretion of TNF-α from macrophages

Abstract Background and aims Acute liver failure (ALF) is a rapidly progressing clinical syndrome with a high mortality rate and limited treatment options. In this study, we used the RIP1 kinase inhibitor necrostatin-1 (Nec-1) to explore the effect and mechanism of RIP1 in lipopolysaccharide (LPS)/D...

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Bibliographic Details
Main Authors: Aichun Li, Dahua Chen, Jianwei Shen
Format: Article
Language:English
Published: BMC 2025-07-01
Series:European Journal of Medical Research
Subjects:
Acute liver failure
RIP1
Apoptosis
TNF-α
Macrophages
Online Access:https://doi.org/10.1186/s40001-025-02948-y
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https://doi.org/10.1186/s40001-025-02948-y

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