A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma
Background. Multiple modalities have been used in the treatment of melasma with variable success. Niacinamide has anti-inflammatory properties and is able to decrease the transfer of melanosomes. Objective. To evaluate the therapeutic effect of topical niacinamide versus hydroquinone (HQ) in melasma...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2011/379173 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556922782351360 |
|---|---|
| author | Josefina Navarrete-Solís Juan Pablo Castanedo-Cázares Bertha Torres-µlvarez Cuauhtemoc Oros-Ovalle Cornelia Fuentes-Ahumada Francisco Javier González Juan David Martínez-Ramírez Benjamin Moncada |
| author_facet | Josefina Navarrete-Solís Juan Pablo Castanedo-Cázares Bertha Torres-µlvarez Cuauhtemoc Oros-Ovalle Cornelia Fuentes-Ahumada Francisco Javier González Juan David Martínez-Ramírez Benjamin Moncada |
| author_sort | Josefina Navarrete-Solís |
| collection | DOAJ |
| description | Background. Multiple modalities have been used in the treatment of melasma with variable success. Niacinamide has anti-inflammatory properties and is able to decrease the transfer of melanosomes. Objective. To evaluate the therapeutic effect of topical niacinamide versus hydroquinone (HQ) in melasma patients. Patients and Methods. Twenty-seven melasma patients were randomized to receive for eight weeks 4% niacinamide cream on one side of the face, and 4% HQ cream on the other. Sunscreen was applied along the observation period. They were assessed by noninvasive techniques for the evaluation of skin color, as well as subjective scales and histological sections initially and after the treatment with niacinamide. Results. All patients showed pigment improvement with both treatments. Colorimetric measures did not show statistical differences between both sides. However, good to excellent improvement was observed with niacinamide in 44% of patients, compared to 55% with HQ. Niacinamide reduced importantly the mast cell infiltrate and showed improvement of solar elastosis in melasma skin. Side effects were present in 18% with niacinamide versus 29% with HQ. Conclusion. Niacinamide induces a decrease in pigmentation, inflammatory infiltrate, and solar elastosis. Niacinamide is a safe and effective therapeutic agent for this condition. |
| format | Article |
| id | doaj-art-e97a19d4f56c4a5c97a6f6ea3889fa2d |
| institution | Kabale University |
| issn | 1687-6105 1687-6113 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Dermatology Research and Practice |
| spelling | doaj-art-e97a19d4f56c4a5c97a6f6ea3889fa2d2025-02-03T05:44:10ZengWileyDermatology Research and Practice1687-61051687-61132011-01-01201110.1155/2011/379173379173A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of MelasmaJosefina Navarrete-Solís0Juan Pablo Castanedo-Cázares1Bertha Torres-µlvarez2Cuauhtemoc Oros-Ovalle3Cornelia Fuentes-Ahumada4Francisco Javier González5Juan David Martínez-Ramírez6Benjamin Moncada7Department of Dermatology, Hospital Central, Universidad Autónoma de San Luis Potosí, San Luis Potosí, MexicoDepartment of Dermatology, Hospital Central, Universidad Autónoma de San Luis Potosí, San Luis Potosí, MexicoDepartment of Dermatology, Hospital Central, Universidad Autónoma de San Luis Potosí, San Luis Potosí, MexicoDepartment of Pathology, Hospital Central, Universidad Autónoma de San Luis Potosí, San Luis Potosí, SLP, MexicoDepartment of Dermatology, Hospital Central, Universidad Autónoma de San Luis Potosí, San Luis Potosí, MexicoCoordinación para la Innovación y la Aplicación de la Ciencia y la Tecnología, Universidad Autónoma de San Luis Potosí, San Luis Potosí, SLP, MexicoCoordinación para la Innovación y la Aplicación de la Ciencia y la Tecnología, Universidad Autónoma de San Luis Potosí, San Luis Potosí, SLP, MexicoDepartment of Dermatology, Hospital Central, Universidad Autónoma de San Luis Potosí, San Luis Potosí, MexicoBackground. Multiple modalities have been used in the treatment of melasma with variable success. Niacinamide has anti-inflammatory properties and is able to decrease the transfer of melanosomes. Objective. To evaluate the therapeutic effect of topical niacinamide versus hydroquinone (HQ) in melasma patients. Patients and Methods. Twenty-seven melasma patients were randomized to receive for eight weeks 4% niacinamide cream on one side of the face, and 4% HQ cream on the other. Sunscreen was applied along the observation period. They were assessed by noninvasive techniques for the evaluation of skin color, as well as subjective scales and histological sections initially and after the treatment with niacinamide. Results. All patients showed pigment improvement with both treatments. Colorimetric measures did not show statistical differences between both sides. However, good to excellent improvement was observed with niacinamide in 44% of patients, compared to 55% with HQ. Niacinamide reduced importantly the mast cell infiltrate and showed improvement of solar elastosis in melasma skin. Side effects were present in 18% with niacinamide versus 29% with HQ. Conclusion. Niacinamide induces a decrease in pigmentation, inflammatory infiltrate, and solar elastosis. Niacinamide is a safe and effective therapeutic agent for this condition.http://dx.doi.org/10.1155/2011/379173 |
| spellingShingle | Josefina Navarrete-Solís Juan Pablo Castanedo-Cázares Bertha Torres-µlvarez Cuauhtemoc Oros-Ovalle Cornelia Fuentes-Ahumada Francisco Javier González Juan David Martínez-Ramírez Benjamin Moncada A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma Dermatology Research and Practice |
| title | A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma |
| title_full | A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma |
| title_fullStr | A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma |
| title_full_unstemmed | A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma |
| title_short | A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma |
| title_sort | double blind randomized clinical trial of niacinamide 4 versus hydroquinone 4 in the treatment of melasma |
| url | http://dx.doi.org/10.1155/2011/379173 |
| work_keys_str_mv | AT josefinanavarretesolis adoubleblindrandomizedclinicaltrialofniacinamide4versushydroquinone4inthetreatmentofmelasma AT juanpablocastanedocazares adoubleblindrandomizedclinicaltrialofniacinamide4versushydroquinone4inthetreatmentofmelasma AT berthatorresμlvarez adoubleblindrandomizedclinicaltrialofniacinamide4versushydroquinone4inthetreatmentofmelasma AT cuauhtemocorosovalle adoubleblindrandomizedclinicaltrialofniacinamide4versushydroquinone4inthetreatmentofmelasma AT corneliafuentesahumada adoubleblindrandomizedclinicaltrialofniacinamide4versushydroquinone4inthetreatmentofmelasma AT franciscojaviergonzalez adoubleblindrandomizedclinicaltrialofniacinamide4versushydroquinone4inthetreatmentofmelasma AT juandavidmartinezramirez adoubleblindrandomizedclinicaltrialofniacinamide4versushydroquinone4inthetreatmentofmelasma AT benjaminmoncada adoubleblindrandomizedclinicaltrialofniacinamide4versushydroquinone4inthetreatmentofmelasma AT josefinanavarretesolis doubleblindrandomizedclinicaltrialofniacinamide4versushydroquinone4inthetreatmentofmelasma AT juanpablocastanedocazares doubleblindrandomizedclinicaltrialofniacinamide4versushydroquinone4inthetreatmentofmelasma AT berthatorresμlvarez doubleblindrandomizedclinicaltrialofniacinamide4versushydroquinone4inthetreatmentofmelasma AT cuauhtemocorosovalle doubleblindrandomizedclinicaltrialofniacinamide4versushydroquinone4inthetreatmentofmelasma AT corneliafuentesahumada doubleblindrandomizedclinicaltrialofniacinamide4versushydroquinone4inthetreatmentofmelasma AT franciscojaviergonzalez doubleblindrandomizedclinicaltrialofniacinamide4versushydroquinone4inthetreatmentofmelasma AT juandavidmartinezramirez doubleblindrandomizedclinicaltrialofniacinamide4versushydroquinone4inthetreatmentofmelasma AT benjaminmoncada doubleblindrandomizedclinicaltrialofniacinamide4versushydroquinone4inthetreatmentofmelasma |