Accurate detection of shared genetic architecture from GWAS summary statistics in the small-sample context.

Assessment of the genetic similarity between two phenotypes can provide insight into a common genetic aetiology and inform the use of pleiotropy-informed, cross-phenotype analytical methods to identify novel genetic associations. The genetic correlation is a well-known means of quantifying and testi...

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Bibliographic Details
Main Authors: Thomas W Willis, Chris Wallace
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-08-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010852&type=printable
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