Hypoxia-mediated HES4 promotes the proliferation and motility of hepatocellular carcinoma cell by enhancing COL4A2 transcription

Abstract Hypoxia is a key feature of hepatocellular carcinoma (HCC) tissues. On one hand, it can drive HCC cell to alter their energy metabolism; on the other hand, it promotes the activation of multiple signaling pathways, thereby facilitating the progression of HCC. This study aims to explore the...

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Bibliographic Details
Main Authors: Pingping Zhao, Hong Xu
Format: Article
Language:English
Published: Springer 2025-07-01
Series:Discover Oncology
Subjects:
Online Access:https://doi.org/10.1007/s12672-025-03152-4
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