Harnessing TAGAP to improve immunotherapy for lung squamous carcinoma treatment by targeting c-Rel in CD4+ T cells

Harnessing TAGAP to improve immunotherapy for lung squamous carcinoma treatment by targeting c-Rel in CD4+ T cells

Abstract Revealing the immunosenescence, particularly in CD4+ T cell function in lung squamous carcinoma (LUSC) assists in devising individual treatment strategies. This study identifies differentially expressed genes (DEGs) between ROS1 mutated (ROS1 MUT) and wild-type (ROS1 WT) LUSC samples from t...

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Bibliographic Details
Main Authors: Peian Cai, Haibo Sun, Tongmeng Jiang, Huawei Li, Dejing Huang, Xiaopei Hao, Wei Wang, Wenqun Xing, Guanghui Liang
Format: Article
Language:English
Published: Springer 2025-02-01
Series:Cancer Immunology, Immunotherapy
Subjects:
T cell activating Rho GTPase-activating protein (TAGAP)
CD4+ T cell
Immunotherapy
Prognosis signature
Lung squamous cell carcinoma (LUSC)
Online Access:https://doi.org/10.1007/s00262-025-03960-1
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https://doi.org/10.1007/s00262-025-03960-1

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