Prostate cancer cell-derived exosomes ZNF667-AS1 reduces TGFBR1 mRNA stability to inhibit Treg expansion and DTX resistance by binding to U2AF1

Prostate cancer cell-derived exosomes ZNF667-AS1 reduces TGFBR1 mRNA stability to inhibit Treg expansion and DTX resistance by binding to U2AF1

Abstract Background Docetaxel (DTX) resistance attenuates anti-tumor effects of DTX on prostate cancer (mCRPC) and drug resistance was related to Treg expansion in tumors. ZNF667-AS1 played a suppressing role in various tumors and tumor-derived exosomes carry lncRNAs to participate in tumor progress...

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Bibliographic Details
Main Authors: Zhenfeng Shi, Wenjing Pu, Min Li, Mierzhayiti Aihemaitijiang, Shuo Li, Xiaoan Zhang, Bide Liu, Min Sun, Jiuzhi Li, Zhiwei Li
Format: Article
Language:English
Published: BMC 2024-10-01
Series:Molecular Medicine
Subjects:
Docetaxel
Tregs
Exosomes
ZNF667-AS1
Prostate cancer
Online Access:https://doi.org/10.1186/s10020-024-00947-z
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https://doi.org/10.1186/s10020-024-00947-z

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