Delayed Cerebral Radiation Necrosis after Neutron Beam Radiation of a Parotid Adenocarcinoma: A Case Report and Review of the Literature
Cerebral radiation necrosis (CRN) is a well described possible complication of radiation for treatment of intracranial pathology. However, CRN as sequelae of radiation to extracranial sites is rare. Neutron beam radiation is a highly potent form of radiotherapy that may be used to treat malignant tu...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Neurological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2014/717984 |
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| author | Christopher S. Hong Hamza N. Gokozan José J. Otero Michael Guiou J. Bradley Elder |
| author_facet | Christopher S. Hong Hamza N. Gokozan José J. Otero Michael Guiou J. Bradley Elder |
| author_sort | Christopher S. Hong |
| collection | DOAJ |
| description | Cerebral radiation necrosis (CRN) is a well described possible complication of radiation for treatment of intracranial pathology. However, CRN as sequelae of radiation to extracranial sites is rare. Neutron beam radiation is a highly potent form of radiotherapy that may be used to treat malignant tumors of the salivary glands. This report describes a patient who underwent neutron beam radiation for a parotid adenocarcinoma and who developed biopsy-confirmed temporal lobe radiation necrosis thirty months later. This represents the longest time interval described to date, from initial neutron radiation for extracranial pathology to development of CRN. Two other detailed case studies exist in the literature and are described in this report. These reports as well as our patient’s case are reviewed, and additional recommendations are made to minimize the development of CRN after extracranial neutron beam radiation. Physicians should include the possible diagnosis of CRN in any patient with new neurologic signs or symptoms and a history of head and neck radiation that included planned fields extending to the base of the skull. Counseling of patients prior to neutron beam radiation should include potential neurologic complications associated with CRN and risks of treatment for CRN including neurosurgical intervention. |
| format | Article |
| id | doaj-art-e8ed92f406854d37835e23f1d3c322e2 |
| institution | Kabale University |
| issn | 2090-6668 2090-6676 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Neurological Medicine |
| spelling | doaj-art-e8ed92f406854d37835e23f1d3c322e22025-02-03T05:48:14ZengWileyCase Reports in Neurological Medicine2090-66682090-66762014-01-01201410.1155/2014/717984717984Delayed Cerebral Radiation Necrosis after Neutron Beam Radiation of a Parotid Adenocarcinoma: A Case Report and Review of the LiteratureChristopher S. Hong0Hamza N. Gokozan1José J. Otero2Michael Guiou3J. Bradley Elder4Department of Neurological Surgery, The Ohio State University Wexner Medical Center, 410 W. 10th Avenue, Doan Hall N1052, Columbus, OH 43210, USADepartment of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USADepartment of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USADepartment of Radiation Oncology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USADepartment of Neurological Surgery, The Ohio State University Wexner Medical Center, 410 W. 10th Avenue, Doan Hall N1052, Columbus, OH 43210, USACerebral radiation necrosis (CRN) is a well described possible complication of radiation for treatment of intracranial pathology. However, CRN as sequelae of radiation to extracranial sites is rare. Neutron beam radiation is a highly potent form of radiotherapy that may be used to treat malignant tumors of the salivary glands. This report describes a patient who underwent neutron beam radiation for a parotid adenocarcinoma and who developed biopsy-confirmed temporal lobe radiation necrosis thirty months later. This represents the longest time interval described to date, from initial neutron radiation for extracranial pathology to development of CRN. Two other detailed case studies exist in the literature and are described in this report. These reports as well as our patient’s case are reviewed, and additional recommendations are made to minimize the development of CRN after extracranial neutron beam radiation. Physicians should include the possible diagnosis of CRN in any patient with new neurologic signs or symptoms and a history of head and neck radiation that included planned fields extending to the base of the skull. Counseling of patients prior to neutron beam radiation should include potential neurologic complications associated with CRN and risks of treatment for CRN including neurosurgical intervention.http://dx.doi.org/10.1155/2014/717984 |
| spellingShingle | Christopher S. Hong Hamza N. Gokozan José J. Otero Michael Guiou J. Bradley Elder Delayed Cerebral Radiation Necrosis after Neutron Beam Radiation of a Parotid Adenocarcinoma: A Case Report and Review of the Literature Case Reports in Neurological Medicine |
| title | Delayed Cerebral Radiation Necrosis after Neutron Beam Radiation of a Parotid Adenocarcinoma: A Case Report and Review of the Literature |
| title_full | Delayed Cerebral Radiation Necrosis after Neutron Beam Radiation of a Parotid Adenocarcinoma: A Case Report and Review of the Literature |
| title_fullStr | Delayed Cerebral Radiation Necrosis after Neutron Beam Radiation of a Parotid Adenocarcinoma: A Case Report and Review of the Literature |
| title_full_unstemmed | Delayed Cerebral Radiation Necrosis after Neutron Beam Radiation of a Parotid Adenocarcinoma: A Case Report and Review of the Literature |
| title_short | Delayed Cerebral Radiation Necrosis after Neutron Beam Radiation of a Parotid Adenocarcinoma: A Case Report and Review of the Literature |
| title_sort | delayed cerebral radiation necrosis after neutron beam radiation of a parotid adenocarcinoma a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2014/717984 |
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