Micheliolide attenuates sepsis-induced acute lung injury by suppressing mitochondrial oxidative stress and PFKFB3-driven glycolysis

Micheliolide attenuates sepsis-induced acute lung injury by suppressing mitochondrial oxidative stress and PFKFB3-driven glycolysis

Abstract Background Sepsis is a potentially fatal condition with a significant risk of death. Acute lung injury (ALI) is a life-threatening complication of sepsis, and the inflammatory response plays a critical role in sepsis-induced ALI. The protective effects of micheliolide (MCL) against renal fi...

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Bibliographic Details
Main Authors: Wenhan Li, Yuhan Li, Linjie Xiao, Zhanzhan Xie, Jun Peng, Wenhui Huang, Xu Li, Ying Meng
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Journal of Translational Medicine
Subjects:
Acute lung injury
Macrophage polarization
Oxidative stress
PFKFB3
Glycolysis
Online Access:https://doi.org/10.1186/s12967-024-05906-0
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https://doi.org/10.1186/s12967-024-05906-0

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