The Presence of Two Distinct Lineages of the Foot-And-Mouth Disease Virus Type A in Russia in 2013–2014 Has Significant Implications for the Epidemiology of the Virus in the Region
Molecular surveillance of FMD epidemiology is a fundamental tool for advancing our understanding of virus biology, monitoring virus evolution, and guiding vaccine design. The accessibility of genetic data will facilitate a more comprehensive delineation of FMDV phylogeny on a global scale. In this s...
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2024-12-01
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| Online Access: | https://www.mdpi.com/1999-4915/17/1/8 |
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| author | Victor V. Nikiforov Sergey A. Noskov Alexander V. Sprygin Mohammad Abed Alhussen Anastasia S. Krylova Taisia V. Erofeeva Svetlana N. Fomina Svetlana R. Kremenchugskaya Fedor I. Korennoy Maxim V. Patrushev Ilya A. Chvala Tamara K. Mayorova Stepan V. Toshchakov |
| author_facet | Victor V. Nikiforov Sergey A. Noskov Alexander V. Sprygin Mohammad Abed Alhussen Anastasia S. Krylova Taisia V. Erofeeva Svetlana N. Fomina Svetlana R. Kremenchugskaya Fedor I. Korennoy Maxim V. Patrushev Ilya A. Chvala Tamara K. Mayorova Stepan V. Toshchakov |
| author_sort | Victor V. Nikiforov |
| collection | DOAJ |
| description | Molecular surveillance of FMD epidemiology is a fundamental tool for advancing our understanding of virus biology, monitoring virus evolution, and guiding vaccine design. The accessibility of genetic data will facilitate a more comprehensive delineation of FMDV phylogeny on a global scale. In this study, we investigated the FMDV strains circulating in Russia during the 2013–2014 period in geographically distant regions utilizing whole genome sequencing followed by maximum-likelihood phylogenetic reconstruction of whole genome and VP1 gene sequences. Phylogenetic analysis showed congruence in the topology of the phylogenetic trees constructed using the complete genome and VP1 gene sequence, clearly demonstrating that the isolates analyzed belong to two distinct genetic lineages: A/SEA97 in the Far East and Iran-05 in the North Caucasus. The A/SEA97 isolates exhibited a close genetic identity to those from China and Mongolia, whereas the Iran-05 isolates demonstrated clusterization with those from Turkey. The vaccine-matching studies with isolates from the Far East and North Caucasus revealed no antigenic homology with A/SEA-97 (r<sub>1</sub> = 0.015–0.29) and A/Iran 05 (r<sub>1</sub> = 0.009–0.17). The close genetic relationship of FMDV in the reported outbreak waves to those from neighboring countries indicates that animal movement could contribute to spillover and virus dispersal. The phylogenetic data reported here provide insight into the molecular epidemiology of FMD in the Eurasia region, elucidating the circulation pattern, molecular evolution, and genetic diversity, which is highly valuable for guiding vaccine designs and improving regional eradication policies. |
| format | Article |
| id | doaj-art-e8cf7f024794420180ec68a5bd81f097 |
| institution | Kabale University |
| issn | 1999-4915 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj-art-e8cf7f024794420180ec68a5bd81f0972025-01-24T13:52:14ZengMDPI AGViruses1999-49152024-12-01171810.3390/v17010008The Presence of Two Distinct Lineages of the Foot-And-Mouth Disease Virus Type A in Russia in 2013–2014 Has Significant Implications for the Epidemiology of the Virus in the RegionVictor V. Nikiforov0Sergey A. Noskov1Alexander V. Sprygin2Mohammad Abed Alhussen3Anastasia S. Krylova4Taisia V. Erofeeva5Svetlana N. Fomina6Svetlana R. Kremenchugskaya7Fedor I. Korennoy8Maxim V. Patrushev9Ilya A. Chvala10Tamara K. Mayorova11Stepan V. Toshchakov12Federal Center for Animal Health FGBI ARRIAH, 600901 Vladimir, RussiaNational Research Center “Kurchatov Institute”, 123182 Moscow, RussiaFederal Center for Animal Health FGBI ARRIAH, 600901 Vladimir, RussiaFederal Center for Animal Health FGBI ARRIAH, 600901 Vladimir, RussiaNational Research Center “Kurchatov Institute”, 123182 Moscow, RussiaNational Research Center “Kurchatov Institute”, 123182 Moscow, RussiaFederal Center for Animal Health FGBI ARRIAH, 600901 Vladimir, RussiaFederal Center for Animal Health FGBI ARRIAH, 600901 Vladimir, RussiaFederal Center for Animal Health FGBI ARRIAH, 600901 Vladimir, RussiaNational Research Center “Kurchatov Institute”, 123182 Moscow, RussiaFederal Center for Animal Health FGBI ARRIAH, 600901 Vladimir, RussiaFederal Center for Animal Health FGBI ARRIAH, 600901 Vladimir, RussiaNational Research Center “Kurchatov Institute”, 123182 Moscow, RussiaMolecular surveillance of FMD epidemiology is a fundamental tool for advancing our understanding of virus biology, monitoring virus evolution, and guiding vaccine design. The accessibility of genetic data will facilitate a more comprehensive delineation of FMDV phylogeny on a global scale. In this study, we investigated the FMDV strains circulating in Russia during the 2013–2014 period in geographically distant regions utilizing whole genome sequencing followed by maximum-likelihood phylogenetic reconstruction of whole genome and VP1 gene sequences. Phylogenetic analysis showed congruence in the topology of the phylogenetic trees constructed using the complete genome and VP1 gene sequence, clearly demonstrating that the isolates analyzed belong to two distinct genetic lineages: A/SEA97 in the Far East and Iran-05 in the North Caucasus. The A/SEA97 isolates exhibited a close genetic identity to those from China and Mongolia, whereas the Iran-05 isolates demonstrated clusterization with those from Turkey. The vaccine-matching studies with isolates from the Far East and North Caucasus revealed no antigenic homology with A/SEA-97 (r<sub>1</sub> = 0.015–0.29) and A/Iran 05 (r<sub>1</sub> = 0.009–0.17). The close genetic relationship of FMDV in the reported outbreak waves to those from neighboring countries indicates that animal movement could contribute to spillover and virus dispersal. The phylogenetic data reported here provide insight into the molecular epidemiology of FMD in the Eurasia region, elucidating the circulation pattern, molecular evolution, and genetic diversity, which is highly valuable for guiding vaccine designs and improving regional eradication policies.https://www.mdpi.com/1999-4915/17/1/8foot-and-mouth diseaseserotype ASEA97Iran-05FMDV outbreakRussia |
| spellingShingle | Victor V. Nikiforov Sergey A. Noskov Alexander V. Sprygin Mohammad Abed Alhussen Anastasia S. Krylova Taisia V. Erofeeva Svetlana N. Fomina Svetlana R. Kremenchugskaya Fedor I. Korennoy Maxim V. Patrushev Ilya A. Chvala Tamara K. Mayorova Stepan V. Toshchakov The Presence of Two Distinct Lineages of the Foot-And-Mouth Disease Virus Type A in Russia in 2013–2014 Has Significant Implications for the Epidemiology of the Virus in the Region Viruses foot-and-mouth disease serotype A SEA97 Iran-05 FMDV outbreak Russia |
| title | The Presence of Two Distinct Lineages of the Foot-And-Mouth Disease Virus Type A in Russia in 2013–2014 Has Significant Implications for the Epidemiology of the Virus in the Region |
| title_full | The Presence of Two Distinct Lineages of the Foot-And-Mouth Disease Virus Type A in Russia in 2013–2014 Has Significant Implications for the Epidemiology of the Virus in the Region |
| title_fullStr | The Presence of Two Distinct Lineages of the Foot-And-Mouth Disease Virus Type A in Russia in 2013–2014 Has Significant Implications for the Epidemiology of the Virus in the Region |
| title_full_unstemmed | The Presence of Two Distinct Lineages of the Foot-And-Mouth Disease Virus Type A in Russia in 2013–2014 Has Significant Implications for the Epidemiology of the Virus in the Region |
| title_short | The Presence of Two Distinct Lineages of the Foot-And-Mouth Disease Virus Type A in Russia in 2013–2014 Has Significant Implications for the Epidemiology of the Virus in the Region |
| title_sort | presence of two distinct lineages of the foot and mouth disease virus type a in russia in 2013 2014 has significant implications for the epidemiology of the virus in the region |
| topic | foot-and-mouth disease serotype A SEA97 Iran-05 FMDV outbreak Russia |
| url | https://www.mdpi.com/1999-4915/17/1/8 |
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