Identifying new targets for improving terpenoid biosynthesis in Yarrowia lipolytica through random genomic cytosine base editing

Abstract Background Genome-scale mutagenesis integrated with high-throughput phenotypic screening and causal mutation mapping serves as a robust paradigm for systemic genetic dissection. Despite the application of non-homologous end joining (NHEJ)-mediated genome editing in Yarrowia lipolytica, the...

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Bibliographic Details
Main Authors: Zhenxia Li, Bo Liu, Rongtao Lv, Zhe Sun, QingYan Li, XueLi Zhang
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Microbial Cell Factories
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Online Access:https://doi.org/10.1186/s12934-025-02819-5
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