Innate immune pathway activated mesenchymal stromal cells improve function and histologic outcomes in a rodent osteoarthritis model

Innate immune pathway activated mesenchymal stromal cells improve function and histologic outcomes in a rodent osteoarthritis model

IntroductionIntra‐articular administration of mesenchymal stromal cells (MSC) has demonstrated anti‐inflammatory and chondroprotective activity in both preclinical models and in randomized clinical trials in patients with osteoarthritis (OA). Nonetheless, precedent from MSC studies in non‐OA models...

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Bibliographic Details
Main Authors: Cody Plaisance, Lyndah Chow, Renata Impastato, Zoë J. Williams, Isabella Sabino, Katie J. Sikes, Kelly S. Santangelo, Steven Dow, Lynn M. Pezzanite
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
osteoarthritis
mesenchymal stromal cell
regenerative therapies
STING
interferon
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2025.1525969/full
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https://www.frontiersin.org/articles/10.3389/fbioe.2025.1525969/full

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