GB Virus C Infection: Clinical Significance
GB virus C (GBV-C) RNA positivity rates were examined in serum specimens from 231 patients with liver disease (23 patients with hepatitis B, 175 patients with hepatitis C, five patients with hepatitis B virus plus hepatitis C virus coinfection, and 28 patients with non-A, non-B, non-C hepatitis) to...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
1999-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1999/430279 |
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| _version_ | 1832567343116451840 |
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| author | Xiang Wei Meng Masafumi Komatsu Shigetoshi Ohshima Kunio Nakane Tomoo Fujii Takashi Goto Kazuo Yoneyama Tomoyuki Kuramitsu Motokazu Mukaide |
| author_facet | Xiang Wei Meng Masafumi Komatsu Shigetoshi Ohshima Kunio Nakane Tomoo Fujii Takashi Goto Kazuo Yoneyama Tomoyuki Kuramitsu Motokazu Mukaide |
| author_sort | Xiang Wei Meng |
| collection | DOAJ |
| description | GB virus C (GBV-C) RNA positivity rates were examined in serum specimens from 231 patients with liver disease (23 patients with hepatitis B, 175 patients with hepatitis C, five patients with hepatitis B virus plus hepatitis C virus coinfection, and 28 patients with non-A, non-B, non-C hepatitis) to clarify the clinical significance of this virus. GBV-C RNA was detected in none of 12 patients with fulminant hepatitis, one of two patients with acute hepatitis positive for hepatitis B surface antigen and one of four patients with acute non-A, non-B, non-C hepatitis. Pathogenetic involvement of GBV-C was suspected in some patients in the latter group. Among patients with the non-B, non-C type of chronic disease, one of seven with cirrhosis (14%) and none with chronic hepatitis or hepatocellular carcinoma were GBV-C-positive. In chronic hepatitis C patients who had received interferon treatment, no difference was found in clinical findings, alanine aminotransferase (ALT) concentrations, histology or response to interferon between 11 patients who were GBV-C RNA-positive and 101 patients who were GBV-C RNA-negative. Moreover, changes in ALT after interferon therapy showed no relation to positivity for GBV-C RNA. On the basis of these findings, GBV-C appears to be an unlikely cause of initiation or progression of chronic hepatic diseases. |
| format | Article |
| id | doaj-art-e8c3df52a1e94ff08e24ed977321bbf1 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 1999-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-e8c3df52a1e94ff08e24ed977321bbf12025-02-03T01:01:49ZengWileyCanadian Journal of Gastroenterology0835-79001999-01-01131081481810.1155/1999/430279GB Virus C Infection: Clinical SignificanceXiang Wei Meng0Masafumi Komatsu1Shigetoshi Ohshima2Kunio Nakane3Tomoo Fujii4Takashi Goto5Kazuo Yoneyama6Tomoyuki Kuramitsu7Motokazu Mukaide8First Department of Internal Medicine, Akita University School of Medicine, 1-1-1 Hondo, Akita City, JapanFirst Department of Internal Medicine, Akita University School of Medicine, 1-1-1 Hondo, Akita City, JapanFirst Department of Internal Medicine, Akita University School of Medicine, 1-1-1 Hondo, Akita City, JapanFirst Department of Internal Medicine, Akita University School of Medicine, 1-1-1 Hondo, Akita City, JapanFirst Department of Internal Medicine, Akita University School of Medicine, 1-1-1 Hondo, Akita City, JapanFirst Department of Internal Medicine, Akita University School of Medicine, 1-1-1 Hondo, Akita City, JapanFirst Department of Internal Medicine, Akita University School of Medicine, 1-1-1 Hondo, Akita City, JapanFirst Department of Internal Medicine, Akita University School of Medicine, 1-1-1 Hondo, Akita City, JapanCenter for Molecular Biology and Cytogenetics, SRL Inc, Tokyo, JapanGB virus C (GBV-C) RNA positivity rates were examined in serum specimens from 231 patients with liver disease (23 patients with hepatitis B, 175 patients with hepatitis C, five patients with hepatitis B virus plus hepatitis C virus coinfection, and 28 patients with non-A, non-B, non-C hepatitis) to clarify the clinical significance of this virus. GBV-C RNA was detected in none of 12 patients with fulminant hepatitis, one of two patients with acute hepatitis positive for hepatitis B surface antigen and one of four patients with acute non-A, non-B, non-C hepatitis. Pathogenetic involvement of GBV-C was suspected in some patients in the latter group. Among patients with the non-B, non-C type of chronic disease, one of seven with cirrhosis (14%) and none with chronic hepatitis or hepatocellular carcinoma were GBV-C-positive. In chronic hepatitis C patients who had received interferon treatment, no difference was found in clinical findings, alanine aminotransferase (ALT) concentrations, histology or response to interferon between 11 patients who were GBV-C RNA-positive and 101 patients who were GBV-C RNA-negative. Moreover, changes in ALT after interferon therapy showed no relation to positivity for GBV-C RNA. On the basis of these findings, GBV-C appears to be an unlikely cause of initiation or progression of chronic hepatic diseases.http://dx.doi.org/10.1155/1999/430279 |
| spellingShingle | Xiang Wei Meng Masafumi Komatsu Shigetoshi Ohshima Kunio Nakane Tomoo Fujii Takashi Goto Kazuo Yoneyama Tomoyuki Kuramitsu Motokazu Mukaide GB Virus C Infection: Clinical Significance Canadian Journal of Gastroenterology |
| title | GB Virus C Infection: Clinical Significance |
| title_full | GB Virus C Infection: Clinical Significance |
| title_fullStr | GB Virus C Infection: Clinical Significance |
| title_full_unstemmed | GB Virus C Infection: Clinical Significance |
| title_short | GB Virus C Infection: Clinical Significance |
| title_sort | gb virus c infection clinical significance |
| url | http://dx.doi.org/10.1155/1999/430279 |
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