Macrophage Notch1 signaling modulates regulatory T cells via the TGFB axis in early MASLD

Macrophage Notch1 signaling modulates regulatory T cells via the TGFB axis in early MASLD

Background & Aims: Hepatic immune imbalance is crucial for driving metabolic dysfunction-associated steatotic liver disease (MASLD) progression. However, the role of hepatic regulatory T cells (Tregs) in MASLD initiation and the mechanisms responsible for their change are not completely unde...

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Bibliographic Details
Main Authors: Mengya Zhang, Kun Li, Xiaoxing Huang, Dongqin Xu, Ruobin Zong, Qintong Hu, Xiaoyu Dong, Qinyong Zhang, Chaochen Jiang, Yue Ge, Changyong Li, Jie Ping
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:JHEP Reports
Subjects:
Hepatic Tregs
Exosomes
Macrophages
Notch1
Hepatic steatosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555924002465
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http://www.sciencedirect.com/science/article/pii/S2589555924002465

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