Bacterial Isolates and Antibiotic Sensitivity among Gambian Children with Severe Acute Malnutrition
Background. Establishing the pattern of infection and antimicrobial sensitivities in the local environment is critical to rational use of antibiotics and the development of management algorithms. Methods. Morbidity history and physical examination of 140 children with severe acute malnutrition were...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | International Journal of Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2011/825123 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556370447040512 |
|---|---|
| author | Uduak A. Okomo Danlami Garba Augustin E. Fombah Ousman Secka Usman N. A. Ikumapayi Jacob. J. Udo Martin O. C. Ota |
| author_facet | Uduak A. Okomo Danlami Garba Augustin E. Fombah Ousman Secka Usman N. A. Ikumapayi Jacob. J. Udo Martin O. C. Ota |
| author_sort | Uduak A. Okomo |
| collection | DOAJ |
| description | Background. Establishing the pattern of infection and antimicrobial sensitivities in the local environment is critical to rational use of antibiotics and the development of management algorithms. Methods. Morbidity history and physical examination of 140 children with severe acute malnutrition were recorded. Their blood, stool, and urine samples were cultured and antibiotic sensitivity patterns determined for any bacterial pathogens isolated. Results. Thirty-eight children had a pathogen isolated from blood culture, 60% of which were considered contaminants. Coagulase negative staphylococcus was the predominant contaminant, while the major causes of bacteraemia were nontyphoidal Salmonella (13%), S. pneumoniae (10%), and E. coli (8%). E. coli accounted for 58% of the urinary isolates. No pathogen was isolated from stool. In vitro sensitivity by disk diffusion showed that 87.5% of the isolates were sensitive to ampicillin and/or gentamicin and 84.4% (27/32) to penicillin and/or gentamicin. Conclusions. A combination of ampicillin and gentamicin provides adequate antibiotic cover for severely malnourished children in The Gambia. |
| format | Article |
| id | doaj-art-e8a4f40d0fe8405a88c1ba9d668cfacf |
| institution | Kabale University |
| issn | 1687-9740 1687-9759 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj-art-e8a4f40d0fe8405a88c1ba9d668cfacf2025-02-03T05:45:35ZengWileyInternational Journal of Pediatrics1687-97401687-97592011-01-01201110.1155/2011/825123825123Bacterial Isolates and Antibiotic Sensitivity among Gambian Children with Severe Acute MalnutritionUduak A. Okomo0Danlami Garba1Augustin E. Fombah2Ousman Secka3Usman N. A. Ikumapayi4Jacob. J. Udo5Martin O. C. Ota6Medical Research Council (UK) Laboratories, Atlantic Road, Fajara, P.O. Box 273, Banjul, GambiaMedical Research Council (UK) Laboratories, Atlantic Road, Fajara, P.O. Box 273, Banjul, GambiaMedical Research Council (UK) Laboratories, Atlantic Road, Fajara, P.O. Box 273, Banjul, GambiaMedical Research Council (UK) Laboratories, Atlantic Road, Fajara, P.O. Box 273, Banjul, GambiaMedical Research Council (UK) Laboratories, Atlantic Road, Fajara, P.O. Box 273, Banjul, GambiaDepartment of Paediatrics, University of Calabar teaching Hospital, PMB 1278, Calabar, Cross River State, NigeriaMedical Research Council (UK) Laboratories, Atlantic Road, Fajara, P.O. Box 273, Banjul, GambiaBackground. Establishing the pattern of infection and antimicrobial sensitivities in the local environment is critical to rational use of antibiotics and the development of management algorithms. Methods. Morbidity history and physical examination of 140 children with severe acute malnutrition were recorded. Their blood, stool, and urine samples were cultured and antibiotic sensitivity patterns determined for any bacterial pathogens isolated. Results. Thirty-eight children had a pathogen isolated from blood culture, 60% of which were considered contaminants. Coagulase negative staphylococcus was the predominant contaminant, while the major causes of bacteraemia were nontyphoidal Salmonella (13%), S. pneumoniae (10%), and E. coli (8%). E. coli accounted for 58% of the urinary isolates. No pathogen was isolated from stool. In vitro sensitivity by disk diffusion showed that 87.5% of the isolates were sensitive to ampicillin and/or gentamicin and 84.4% (27/32) to penicillin and/or gentamicin. Conclusions. A combination of ampicillin and gentamicin provides adequate antibiotic cover for severely malnourished children in The Gambia.http://dx.doi.org/10.1155/2011/825123 |
| spellingShingle | Uduak A. Okomo Danlami Garba Augustin E. Fombah Ousman Secka Usman N. A. Ikumapayi Jacob. J. Udo Martin O. C. Ota Bacterial Isolates and Antibiotic Sensitivity among Gambian Children with Severe Acute Malnutrition International Journal of Pediatrics |
| title | Bacterial Isolates and Antibiotic Sensitivity among Gambian Children with Severe Acute Malnutrition |
| title_full | Bacterial Isolates and Antibiotic Sensitivity among Gambian Children with Severe Acute Malnutrition |
| title_fullStr | Bacterial Isolates and Antibiotic Sensitivity among Gambian Children with Severe Acute Malnutrition |
| title_full_unstemmed | Bacterial Isolates and Antibiotic Sensitivity among Gambian Children with Severe Acute Malnutrition |
| title_short | Bacterial Isolates and Antibiotic Sensitivity among Gambian Children with Severe Acute Malnutrition |
| title_sort | bacterial isolates and antibiotic sensitivity among gambian children with severe acute malnutrition |
| url | http://dx.doi.org/10.1155/2011/825123 |
| work_keys_str_mv | AT uduakaokomo bacterialisolatesandantibioticsensitivityamonggambianchildrenwithsevereacutemalnutrition AT danlamigarba bacterialisolatesandantibioticsensitivityamonggambianchildrenwithsevereacutemalnutrition AT augustinefombah bacterialisolatesandantibioticsensitivityamonggambianchildrenwithsevereacutemalnutrition AT ousmansecka bacterialisolatesandantibioticsensitivityamonggambianchildrenwithsevereacutemalnutrition AT usmannaikumapayi bacterialisolatesandantibioticsensitivityamonggambianchildrenwithsevereacutemalnutrition AT jacobjudo bacterialisolatesandantibioticsensitivityamonggambianchildrenwithsevereacutemalnutrition AT martinocota bacterialisolatesandantibioticsensitivityamonggambianchildrenwithsevereacutemalnutrition |