Ablation of lipocalin-2 reduces neuroinflammation in a mouse model of Krabbe disease

Ablation of lipocalin-2 reduces neuroinflammation in a mouse model of Krabbe disease

Abstract Lipocalin-2 (LCN2) is an acute-phase secretory molecule significantly upregulated in various neuroinflammatory and demyelinating conditions. Krabbe disease (KD) is a neurodegenerative lysosomal disorder caused by a galactosylceramidase (GALC) deficiency, accumulating cytotoxic psychosine in...

Full description

Saved in:
Bibliographic Details
Main Authors: Jacob Favret, Malabika Maulik, Rayan Masoom, Meghana Kushwaha, Devin Thompson, Richard Browne, Daesung Shin
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Lysosomal storage disorder
Krabbe disease
Globoid cell leukodystrophy
Galactosylceramidase
Psychosine
Lipocalin-2
Online Access:https://doi.org/10.1038/s41598-024-82927-1
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1038/s41598-024-82927-1

Similar Items