Blocking Notch signal pathway delayed uric acid-induced renal injury in rats

Blocking Notch signal pathway delayed uric acid-induced renal injury in rats

ObjectiveTo investigate the effect and mechanism of γ-secretase inhibitor DAPT on uric acid-induced renal injury in rats.MethodsTwenty-one male SD rats were randomly divided into normal control group （control， <italic>n</italic>=7）， hyperuricemia model group （OA+UA， <italic>n</i...

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Bibliographic Details
Main Authors: Shen Yu-li, Pan Fu-lin, Fu Jun-zhou, Zhang Xin-zhou
Format: Article
Language:zho
Published: Editorial Department of Journal of Clinical Nephrology 2022-11-01
Series:Linchuang shenzangbing zazhi
Subjects:
Notch1/Jagged1
DAPT
Rats
Renal injury
Uric acid
Online Access:http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2022.11.009
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