Valproic Acid-Induced Hyperammonemia in the Elderly: A Review of the Literature

Valproic acid and its derivatives are commonly used to treat many psychiatric conditions in the elderly. Hyperammonemia is a less common but important side effect of these drugs. The elderly patient appears highly vulnerable to this side effect of this group of medications. In this paper, we systema...

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Main Authors: Vikrant Mittal, Sunanda Muralee, Rajesh R. Tampi
Format: Article
Language:English
Published: Wiley 2009-01-01
Series:Case Reports in Medicine
Online Access:http://dx.doi.org/10.1155/2009/802121
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author Vikrant Mittal
Sunanda Muralee
Rajesh R. Tampi
author_facet Vikrant Mittal
Sunanda Muralee
Rajesh R. Tampi
author_sort Vikrant Mittal
collection DOAJ
description Valproic acid and its derivatives are commonly used to treat many psychiatric conditions in the elderly. Hyperammonemia is a less common but important side effect of these drugs. The elderly patient appears highly vulnerable to this side effect of this group of medications. In this paper, we systematically review the published literature for hyperammonemia induced by valproic acid and its derivatives. We describe the three reported cases and review possible treatment strategies for this condition.
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spelling doaj-art-e85ea7a6790041b2bc86cf06437482c42025-02-03T01:10:58ZengWileyCase Reports in Medicine1687-96271687-96352009-01-01200910.1155/2009/802121802121Valproic Acid-Induced Hyperammonemia in the Elderly: A Review of the LiteratureVikrant Mittal0Sunanda Muralee1Rajesh R. Tampi2Parkland Health Center, 1103 West Liberty Street, Farmington, MO 63640, USAYale New Haven Psychiatric Hospital, 184 Liberty Street, New Haven, CT 06519, USAYale New Haven Psychiatric Hospital, 184 Liberty Street, New Haven, CT 06519, USAValproic acid and its derivatives are commonly used to treat many psychiatric conditions in the elderly. Hyperammonemia is a less common but important side effect of these drugs. The elderly patient appears highly vulnerable to this side effect of this group of medications. In this paper, we systematically review the published literature for hyperammonemia induced by valproic acid and its derivatives. We describe the three reported cases and review possible treatment strategies for this condition.http://dx.doi.org/10.1155/2009/802121
spellingShingle Vikrant Mittal
Sunanda Muralee
Rajesh R. Tampi
Valproic Acid-Induced Hyperammonemia in the Elderly: A Review of the Literature
Case Reports in Medicine
title Valproic Acid-Induced Hyperammonemia in the Elderly: A Review of the Literature
title_full Valproic Acid-Induced Hyperammonemia in the Elderly: A Review of the Literature
title_fullStr Valproic Acid-Induced Hyperammonemia in the Elderly: A Review of the Literature
title_full_unstemmed Valproic Acid-Induced Hyperammonemia in the Elderly: A Review of the Literature
title_short Valproic Acid-Induced Hyperammonemia in the Elderly: A Review of the Literature
title_sort valproic acid induced hyperammonemia in the elderly a review of the literature
url http://dx.doi.org/10.1155/2009/802121
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AT rajeshrtampi valproicacidinducedhyperammonemiaintheelderlyareviewoftheliterature