IGF2BP3 enhances ferroptosis resistance in colon cancer by stabilizing SLC7A11 and is regulated by miR-98-5p

IGF2BP3 enhances ferroptosis resistance in colon cancer by stabilizing SLC7A11 and is regulated by miR-98-5p

PurposeColon cancer remains a global health challenge with rising mortality, necessitating novel therapeutic strategies. IGF2BP3, an oncogenic RNA-binding protein, is implicated in colon cancer progression, while its role in ferroptosis regulation remains unclear. This study investigates IGF2BP3’s r...

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Bibliographic Details
Main Authors: Yaya Sun, Qingwei Liu, Junjie Wu, Guangqing Jiang, Hongzhou Shi, Yihong Zhang, Yanxuan Ling, Weimin Sun, Xin Shi, Congxing Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Oncology
Subjects:
IGF2BP3
colon cancer
ferroptosis
miR-98-5p
SLC7A11
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1576895/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1576895/full

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