Pretransplant Fasting Glucose Predicts New-Onset Diabetes after Liver Transplantation
New-onset diabetes after transplantation (NODAT) is common after liver transplant and associated with poorer outcomes. The aim of this study was to identify risk factors for NODAT in liver transplant recipients off corticosteroids. In 225 adult nondiabetic liver transplant recipients, the mean age w...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2012/614781 |
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| author | Elizabeth J. Carey Bashar A. Aqel Thomas J. Byrne David D. Douglas Jorge Rakela Hugo E. Vargas Adyr A. Moss David C. Mulligan K. Sudhakar Reddy Harini A. Chakkera |
| author_facet | Elizabeth J. Carey Bashar A. Aqel Thomas J. Byrne David D. Douglas Jorge Rakela Hugo E. Vargas Adyr A. Moss David C. Mulligan K. Sudhakar Reddy Harini A. Chakkera |
| author_sort | Elizabeth J. Carey |
| collection | DOAJ |
| description | New-onset diabetes after transplantation (NODAT) is common after liver transplant and associated with poorer outcomes. The aim of this study was to identify risk factors for NODAT in liver transplant recipients off corticosteroids. In 225 adult nondiabetic liver transplant recipients, the mean age was 51.7 years, the majority were men (71%), and half had HCV (49%). The mean calculated MELD score at transplantation was 18.7, and 19% underwent living-donor transplant (LDLT). One year after transplantation, 17% developed NODAT, and an additional 16% had impaired fasting glucose. The incidence of NODAT in patients with HCV was 26%. In multivariate analysis, HCV, pretransplant FPG, and LDLT were significant. Each 10 mg/dL increase in pretransplant FPG was associated with a twofold increase in future development of NODAT. The incidence of NODAT after liver transplant in patients off corticosteroids is 17%. Risk factors for developing NODAT include HCV and pretransplant FPG; LDLT is protective. |
| format | Article |
| id | doaj-art-e83518d3e04a4ab4920c811ceef50d29 |
| institution | Kabale University |
| issn | 2090-0007 2090-0015 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Transplantation |
| spelling | doaj-art-e83518d3e04a4ab4920c811ceef50d292025-02-03T05:53:41ZengWileyJournal of Transplantation2090-00072090-00152012-01-01201210.1155/2012/614781614781Pretransplant Fasting Glucose Predicts New-Onset Diabetes after Liver TransplantationElizabeth J. Carey0Bashar A. Aqel1Thomas J. Byrne2David D. Douglas3Jorge Rakela4Hugo E. Vargas5Adyr A. Moss6David C. Mulligan7K. Sudhakar Reddy8Harini A. Chakkera9Division of Hepatology, Mayo Clinic Arizona, 5777 E. Mayo Boulevard, Phoenix, AZ 85054, USADivision of Hepatology, Mayo Clinic Arizona, 5777 E. Mayo Boulevard, Phoenix, AZ 85054, USADivision of Hepatology, Mayo Clinic Arizona, 5777 E. Mayo Boulevard, Phoenix, AZ 85054, USADivision of Hepatology, Mayo Clinic Arizona, 5777 E. Mayo Boulevard, Phoenix, AZ 85054, USADivision of Hepatology, Mayo Clinic Arizona, 5777 E. Mayo Boulevard, Phoenix, AZ 85054, USADivision of Hepatology, Mayo Clinic Arizona, 5777 E. Mayo Boulevard, Phoenix, AZ 85054, USADivision of Transplant Surgery, Mayo Clinic Arizona, Phoenix, AZ 85054, USADivision of Transplant Surgery, Mayo Clinic Arizona, Phoenix, AZ 85054, USADivision of Transplant Surgery, Mayo Clinic Arizona, Phoenix, AZ 85054, USADivision of Nephrology, Mayo Clinic Arizona, Phoenix, AZ 85054, USANew-onset diabetes after transplantation (NODAT) is common after liver transplant and associated with poorer outcomes. The aim of this study was to identify risk factors for NODAT in liver transplant recipients off corticosteroids. In 225 adult nondiabetic liver transplant recipients, the mean age was 51.7 years, the majority were men (71%), and half had HCV (49%). The mean calculated MELD score at transplantation was 18.7, and 19% underwent living-donor transplant (LDLT). One year after transplantation, 17% developed NODAT, and an additional 16% had impaired fasting glucose. The incidence of NODAT in patients with HCV was 26%. In multivariate analysis, HCV, pretransplant FPG, and LDLT were significant. Each 10 mg/dL increase in pretransplant FPG was associated with a twofold increase in future development of NODAT. The incidence of NODAT after liver transplant in patients off corticosteroids is 17%. Risk factors for developing NODAT include HCV and pretransplant FPG; LDLT is protective.http://dx.doi.org/10.1155/2012/614781 |
| spellingShingle | Elizabeth J. Carey Bashar A. Aqel Thomas J. Byrne David D. Douglas Jorge Rakela Hugo E. Vargas Adyr A. Moss David C. Mulligan K. Sudhakar Reddy Harini A. Chakkera Pretransplant Fasting Glucose Predicts New-Onset Diabetes after Liver Transplantation Journal of Transplantation |
| title | Pretransplant Fasting Glucose Predicts New-Onset Diabetes after Liver Transplantation |
| title_full | Pretransplant Fasting Glucose Predicts New-Onset Diabetes after Liver Transplantation |
| title_fullStr | Pretransplant Fasting Glucose Predicts New-Onset Diabetes after Liver Transplantation |
| title_full_unstemmed | Pretransplant Fasting Glucose Predicts New-Onset Diabetes after Liver Transplantation |
| title_short | Pretransplant Fasting Glucose Predicts New-Onset Diabetes after Liver Transplantation |
| title_sort | pretransplant fasting glucose predicts new onset diabetes after liver transplantation |
| url | http://dx.doi.org/10.1155/2012/614781 |
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