The Ameliorative Effect of Adipose-Derived Mesenchymal Stem Cells and Their Exosomes in Non-alcoholic Steatohepatitis by Simultaneously Enhancing Autophagic Flux and Suppressing Endoplasmic Reticulum Stress

The Ameliorative Effect of Adipose-Derived Mesenchymal Stem Cells and Their Exosomes in Non-alcoholic Steatohepatitis by Simultaneously Enhancing Autophagic Flux and Suppressing Endoplasmic Reticulum Stress

Background: Due to the scarcity of treatment options, managing the progression of non-alcoholic fatty liver disease (NAFLD) from steatosis to cirrhosis necessitates innovative approaches. This study focused on endoplasmic reticulum (ER) stress, apoptosis, and autophagy as key mechanisms in NAFLD pat...

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Main Authors: Zahra Moayedfard, Kamran Lankarani, Ali Akbar Alizadeh, Ali Akbar Nekooeian, Mahintaj Dara, Farhad Koohpeyma, Shima Parsa, Saman Nikeghbalian, Arghavan Hosseinpouri, Negar Azarpira
Format: Article
Language:English
Published: Shiraz University of Medical Sciences 2025-05-01
Series:Iranian Journal of Medical Sciences
Subjects:
non-alcoholic fatty liver disease
mesenchymal stem cells
exosome
autophagy
endoplasmic reticulum stress
Online Access:https://ijms.sums.ac.ir/article_50757_7527c43e82dd45e57bdf82265506acff.pdf
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