Histone Deacetylase Inhibitor Scriptaid Alleviated Neurological Dysfunction after Experimental Intracerebral Hemorrhage in Mice
Objectives. To investigate the role of Scriptaid in reducing brain injury after intracerebral hemorrhage (ICH) in mice. Methods. An ICH model was constructed by injecting autologous blood into the right basal ganglia in mice. The animals were administered 3.5 mg/kg of Scriptaid intraperitoneally aft...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2018/6583267 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832553980742336512 |
|---|---|
| author | Heng Yang Wei Ni Hanqiang Jiang Yu Lei Jiabin Su Yuxiang Gu Liangfu Zhou |
| author_facet | Heng Yang Wei Ni Hanqiang Jiang Yu Lei Jiabin Su Yuxiang Gu Liangfu Zhou |
| author_sort | Heng Yang |
| collection | DOAJ |
| description | Objectives. To investigate the role of Scriptaid in reducing brain injury after intracerebral hemorrhage (ICH) in mice. Methods. An ICH model was constructed by injecting autologous blood into the right basal ganglia in mice. The animals were administered 3.5 mg/kg of Scriptaid intraperitoneally after ICH. The hematoma volume and hemoglobin level were measured to examine hematoma resolution. A behavior test and brain edema and white matter injury examinations indicated brain injury after ICH. Results. Scriptaid treatment promoted hematoma resolution and reduced the hematoma volume 7 d after ICH compared with the vehicle group (P<0.05). Scriptaid treatment also alleviated the brain water content in the ipsilateral basal ganglia (P<0.05) and cortex (P<0.01) 3 d after ICH. In addition, Scriptaid improved neurological function recovery and alleviated white matter injury 35 d after ICH. Conclusions. Scriptaid can protect against brain injury after ICH and may be considered a new medical therapy method for ICH. |
| format | Article |
| id | doaj-art-e82fe12361be4e6d848c385cc700ce4f |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-e82fe12361be4e6d848c385cc700ce4f2025-02-03T05:52:46ZengWileyBehavioural Neurology0953-41801875-85842018-01-01201810.1155/2018/65832676583267Histone Deacetylase Inhibitor Scriptaid Alleviated Neurological Dysfunction after Experimental Intracerebral Hemorrhage in MiceHeng Yang0Wei Ni1Hanqiang Jiang2Yu Lei3Jiabin Su4Yuxiang Gu5Liangfu Zhou6Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, ChinaObjectives. To investigate the role of Scriptaid in reducing brain injury after intracerebral hemorrhage (ICH) in mice. Methods. An ICH model was constructed by injecting autologous blood into the right basal ganglia in mice. The animals were administered 3.5 mg/kg of Scriptaid intraperitoneally after ICH. The hematoma volume and hemoglobin level were measured to examine hematoma resolution. A behavior test and brain edema and white matter injury examinations indicated brain injury after ICH. Results. Scriptaid treatment promoted hematoma resolution and reduced the hematoma volume 7 d after ICH compared with the vehicle group (P<0.05). Scriptaid treatment also alleviated the brain water content in the ipsilateral basal ganglia (P<0.05) and cortex (P<0.01) 3 d after ICH. In addition, Scriptaid improved neurological function recovery and alleviated white matter injury 35 d after ICH. Conclusions. Scriptaid can protect against brain injury after ICH and may be considered a new medical therapy method for ICH.http://dx.doi.org/10.1155/2018/6583267 |
| spellingShingle | Heng Yang Wei Ni Hanqiang Jiang Yu Lei Jiabin Su Yuxiang Gu Liangfu Zhou Histone Deacetylase Inhibitor Scriptaid Alleviated Neurological Dysfunction after Experimental Intracerebral Hemorrhage in Mice Behavioural Neurology |
| title | Histone Deacetylase Inhibitor Scriptaid Alleviated Neurological Dysfunction after Experimental Intracerebral Hemorrhage in Mice |
| title_full | Histone Deacetylase Inhibitor Scriptaid Alleviated Neurological Dysfunction after Experimental Intracerebral Hemorrhage in Mice |
| title_fullStr | Histone Deacetylase Inhibitor Scriptaid Alleviated Neurological Dysfunction after Experimental Intracerebral Hemorrhage in Mice |
| title_full_unstemmed | Histone Deacetylase Inhibitor Scriptaid Alleviated Neurological Dysfunction after Experimental Intracerebral Hemorrhage in Mice |
| title_short | Histone Deacetylase Inhibitor Scriptaid Alleviated Neurological Dysfunction after Experimental Intracerebral Hemorrhage in Mice |
| title_sort | histone deacetylase inhibitor scriptaid alleviated neurological dysfunction after experimental intracerebral hemorrhage in mice |
| url | http://dx.doi.org/10.1155/2018/6583267 |
| work_keys_str_mv | AT hengyang histonedeacetylaseinhibitorscriptaidalleviatedneurologicaldysfunctionafterexperimentalintracerebralhemorrhageinmice AT weini histonedeacetylaseinhibitorscriptaidalleviatedneurologicaldysfunctionafterexperimentalintracerebralhemorrhageinmice AT hanqiangjiang histonedeacetylaseinhibitorscriptaidalleviatedneurologicaldysfunctionafterexperimentalintracerebralhemorrhageinmice AT yulei histonedeacetylaseinhibitorscriptaidalleviatedneurologicaldysfunctionafterexperimentalintracerebralhemorrhageinmice AT jiabinsu histonedeacetylaseinhibitorscriptaidalleviatedneurologicaldysfunctionafterexperimentalintracerebralhemorrhageinmice AT yuxianggu histonedeacetylaseinhibitorscriptaidalleviatedneurologicaldysfunctionafterexperimentalintracerebralhemorrhageinmice AT liangfuzhou histonedeacetylaseinhibitorscriptaidalleviatedneurologicaldysfunctionafterexperimentalintracerebralhemorrhageinmice |