Citrus flavonoids for overcoming breast cancer resistance to methotrexate: identification of potential targets of nobiletin and sinensetin

Citrus flavonoids for overcoming breast cancer resistance to methotrexate: identification of potential targets of nobiletin and sinensetin

Abstract Breast cancer is a potentially fatal illness that affects millions of women worldwide. Methotrexate (MTX) may be beneficial for treating breast cancer; however, high doses and prolonged use can cause drug resistance. Although certain citrus flavonoids—nobiletin, sinensetin, tangeretin, hesp...

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Bibliographic Details
Main Authors: Adam Hermawan, Naufa Hanif, Dyaningtyas Dewi Pamungkas Putri, Nurul Fatimah, Heri Himawan Prasetio
Format: Article
Language:English
Published: Springer 2025-03-01
Series:Discover Oncology
Subjects:
Methotrexate resistance
Breast cancer
Citrus flavonoids
Nobiletin
Sinensetin
Online Access:https://doi.org/10.1007/s12672-025-02116-y
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https://doi.org/10.1007/s12672-025-02116-y

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