Transferability of bioprocessing modes for recombinant protease production: from fed-batch to continuous cultivation with Bacillus licheniformis

Transferability of bioprocessing modes for recombinant protease production: from fed-batch to continuous cultivation with Bacillus licheniformis

Abstract Background Proteases are essential in various industries due to their unique substrate specificities and robustness in different operational conditions. Bacillus strains consist of a genotype favorable for rapid growth whilst secreting enzymes extracellularly, thereby simplifying recombinan...

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Bibliographic Details
Main Authors: Stefan Kittler, Fabian Müller, Mohamed Elshazly, Georg Benjamin Wandrey, Tobias Klein, Andreas Daub, Oliver Spadiut, Julian Kopp
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Biotechnology
Subjects:
Bacillus licheniformis
Continuous processing
Model-based development
Sustainable processing
Fed-batch
Chemostat
Online Access:https://doi.org/10.1186/s12896-025-00947-9
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https://doi.org/10.1186/s12896-025-00947-9

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