Rare damaging variants in the sex differences of congenital heart disease: an exome sequencing studyResearch in context

Rare damaging variants in the sex differences of congenital heart disease: an exome sequencing studyResearch in context

Summary: Background: Congenital heart disease (CHD) exhibits a marked male predominance in birth prevalence, yet the genetic mechanisms underlying this sex disparity remain poorly understood. This study investigates the contribution of rare damaging variants on autosomes and the X chromosome to sex...

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Main Authors: Hairui Sun, Xiaoyan Hao, Hankui Liu, Siyao Zhang, Jiancheng Han, Ye Zhang, Tingting Liu, Xian Yang, Hairui Wang, Jiaqi Fan, Yuxuan Guan, Ni Peng, Jiaoyang Xie, Hongmei Xia, Xueqin Ji, Yan Xu, Jianguo Zhang, Jianbin Wang, Feng Lan, Hongjia Zhang, Xiaoyan Gu, Yihua He
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:EBioMedicine
Subjects:
Congenital heart disease
Sex differences
Whole exome sequencing
Pediatric
Prenatal
Online Access:http://www.sciencedirect.com/science/article/pii/S235239642500180X
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http://www.sciencedirect.com/science/article/pii/S235239642500180X

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