Lack of Matrilin-2 favors liver tumor development via Erk1/2 and GSK-3β pathways in vivo.

Lack of Matrilin-2 favors liver tumor development via Erk1/2 and GSK-3β pathways in vivo.

Matrilin-2 (Matn2) is a multidomain adaptor protein which plays a role in the assembly of extracellular matrix (ECM). It is produced by oval cells during stem cell-driven liver regeneration. In our study, the impact of Matn2 on hepatocarcinogenesis was investigated in Matn2(-/-) mice comparing them...

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Main Authors: Alexandra Fullár, Kornélia Baghy, Ferenc Deák, Bálint Péterfia, Yvonne Zsák, Péter Tátrai, Zsuzsa Schaff, József Dudás, Ibolya Kiss, Ilona Kovalszky
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0093469
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https://doi.org/10.1371/journal.pone.0093469

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