FOXA2/miR-148a-3p/SMURF2 signaling feed-forward loop alleviates spinal cord ischemia-reperfusion injury-induced neuropathic pain by modulating microglia polarization in rats

FOXA2/miR-148a-3p/SMURF2 signaling feed-forward loop alleviates spinal cord ischemia-reperfusion injury-induced neuropathic pain by modulating microglia polarization in rats

BackgroundMicroglia polarization is crucial in mediating neuropathic pain. However, the role of microglia polarization in regulating spinal cord ischemia-reperfusion injury (SCIRI)-induced neuropathic pain is largely unknown. This study aimed to elucidate the relationship between SCIRI-induced neuro...

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Main Authors: Xiaotong Hao, Linyan Cao, Jinshi Li, Qian Lei, Xuan Liu, Yuanyuan Li, Yiting Fan, Jingjing Xu, Bo Fang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
smurf2
SIRT1
miR-148a-3p
foxa2
spinal cord ischemia-reperfusion injury
neuropathic pain
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1563377/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1563377/full

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