Targeting RNA splicing modulation: new perspectives for anticancer strategy?

Targeting RNA splicing modulation: new perspectives for anticancer strategy?

Abstract The excision of introns from pre-mRNA is a crucial process in the expression of the majority of genes. Alternative splicing allows a single gene to generate diverse mRNA and protein products. Aberrant RNA splicing is recognized as a molecular characteristic present in almost all types of tu...

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Bibliographic Details
Main Authors: Xuemei Lv, Xiaoyu Sun, Yang Gao, Xinyue Song, Xiaoyun Hu, Lang Gong, Li Han, Miao He, Minjie Wei
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Cancer
Alternative splicing
Splicing modulators
Splice-switching ASO
Targeted therapy
Online Access:https://doi.org/10.1186/s13046-025-03279-w
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