Glucose Deprivation Enhances the Antiproliferative Effects of Oral Hypoglycemic Biguanides in Different Molecular Subtypes of Breast Cancer: an in Vitro Study
Extensive in vitro studies have been conducted to evaluate the anticancer activity of oral hypoglycemic agents. Many of these studies experienced detrimental limitations, since they were conducted on cancer cells commonly grown in culture media consisting of extremely high concentrations of growth f...
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| Format: | Article |
| Language: | English |
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Sciendo
2018-12-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2018-0031 |
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| author | Bardaweel Sanaa K. Alsalamat Husam A. Aleidi Shereen M. Bashatwah Rasha M. |
| author_facet | Bardaweel Sanaa K. Alsalamat Husam A. Aleidi Shereen M. Bashatwah Rasha M. |
| author_sort | Bardaweel Sanaa K. |
| collection | DOAJ |
| description | Extensive in vitro studies have been conducted to evaluate the anticancer activity of oral hypoglycemic agents. Many of these studies experienced detrimental limitations, since they were conducted on cancer cells commonly grown in culture media consisting of extremely high concentrations of growth factors and glucose. The present study was aimed at exploring the antiproliferative effects of the commonly studied metformin and the less frequently reported phenformin oral hypoglycemic agents on different molecular subtypes of breast cancer under rich glucose and glucose deprived conditions. Our results indicate that under glucose deprived conditions, which better reflect the factual glucose-starved solid tumors in vivo, biguanides exert more antiproliferative activities against the three molecular subtypes of breast cancer cell lines examined in this study. In addition, the observed antiproliferative activities of biguanides appear to be mediated by apoptosis induction in breast cancer cells. This induction is significantly augmented under glucose deprived conditions. |
| format | Article |
| id | doaj-art-e781abd2ab4d4835b4c8577a12629b5f |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2018-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-e781abd2ab4d4835b4c8577a12629b5f2025-02-02T12:01:39ZengSciendoActa Pharmaceutica1846-95582018-12-0168451752410.2478/acph-2018-0031acph-2018-0031Glucose Deprivation Enhances the Antiproliferative Effects of Oral Hypoglycemic Biguanides in Different Molecular Subtypes of Breast Cancer: an in Vitro StudyBardaweel Sanaa K.0Alsalamat Husam A.1Aleidi Shereen M.2Bashatwah Rasha M.3Department of Pharmaceutical Sciences, School of Pharmacy University of Jordan,Amman 11942, JordanDepartment of Pharmaceutical Sciences, School of Pharmacy University of Jordan,Amman 11942, JordanDepartment of Biopharmaceutics and Clinical Pharmacy, School of Pharmacy, University of Jordan Amman 11942,Jordan Amman, JordanDepartment of Pharmaceutical Sciences, School of Pharmacy University of Jordan,Amman 11942, JordanExtensive in vitro studies have been conducted to evaluate the anticancer activity of oral hypoglycemic agents. Many of these studies experienced detrimental limitations, since they were conducted on cancer cells commonly grown in culture media consisting of extremely high concentrations of growth factors and glucose. The present study was aimed at exploring the antiproliferative effects of the commonly studied metformin and the less frequently reported phenformin oral hypoglycemic agents on different molecular subtypes of breast cancer under rich glucose and glucose deprived conditions. Our results indicate that under glucose deprived conditions, which better reflect the factual glucose-starved solid tumors in vivo, biguanides exert more antiproliferative activities against the three molecular subtypes of breast cancer cell lines examined in this study. In addition, the observed antiproliferative activities of biguanides appear to be mediated by apoptosis induction in breast cancer cells. This induction is significantly augmented under glucose deprived conditions.https://doi.org/10.2478/acph-2018-0031biguanidebreast cancerapoptosisglucoseampk |
| spellingShingle | Bardaweel Sanaa K. Alsalamat Husam A. Aleidi Shereen M. Bashatwah Rasha M. Glucose Deprivation Enhances the Antiproliferative Effects of Oral Hypoglycemic Biguanides in Different Molecular Subtypes of Breast Cancer: an in Vitro Study Acta Pharmaceutica biguanide breast cancer apoptosis glucose ampk |
| title | Glucose Deprivation Enhances the Antiproliferative Effects of Oral Hypoglycemic Biguanides in Different Molecular Subtypes of Breast Cancer: an in Vitro Study |
| title_full | Glucose Deprivation Enhances the Antiproliferative Effects of Oral Hypoglycemic Biguanides in Different Molecular Subtypes of Breast Cancer: an in Vitro Study |
| title_fullStr | Glucose Deprivation Enhances the Antiproliferative Effects of Oral Hypoglycemic Biguanides in Different Molecular Subtypes of Breast Cancer: an in Vitro Study |
| title_full_unstemmed | Glucose Deprivation Enhances the Antiproliferative Effects of Oral Hypoglycemic Biguanides in Different Molecular Subtypes of Breast Cancer: an in Vitro Study |
| title_short | Glucose Deprivation Enhances the Antiproliferative Effects of Oral Hypoglycemic Biguanides in Different Molecular Subtypes of Breast Cancer: an in Vitro Study |
| title_sort | glucose deprivation enhances the antiproliferative effects of oral hypoglycemic biguanides in different molecular subtypes of breast cancer an in vitro study |
| topic | biguanide breast cancer apoptosis glucose ampk |
| url | https://doi.org/10.2478/acph-2018-0031 |
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