Moderate-intensity interval exercise exacerbates cardiac lipotoxicity in high-fat, high-calories diet-fed mice

Moderate-intensity interval exercise exacerbates cardiac lipotoxicity in high-fat, high-calories diet-fed mice

Abstract Physical exercise is a cornerstone for preventing diet-induced obesity, while it is unclear whether physical exercise could offset high-fat, high-calories diet (HFCD)-induced cardiac dysfunction. Here, mice were fed with HFCD and simultaneously subjected to physical exercise. As expected, p...

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Main Authors: Jing Geng, Xiaoliang Zhang, Yanjie Guo, He Wen, Dong Guo, Qi Liang, Siying Pu, Ying Wang, Mingchuan Liu, Zhelong Li, Wei Hu, Xue Yang, Pan Chang, Lang Hu, Yan Li
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-55917-8
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