Based on bioinformatics, SESN2 negatively regulates ferroptosis induced by ischemia reperfusion via the System Xc−/GPX4 pathway

Based on bioinformatics, SESN2 negatively regulates ferroptosis induced by ischemia reperfusion via the System Xc−/GPX4 pathway

IntroductionCerebral ischemia–reperfusion (IR) causes severe secondary brain injury. Previous studies have demonstrated that ferroptosis is involved in IR-induced brain injury. However, whether IR induces ferroptosis in brain microvascular endothelial cells (BMVECs) is not fully understood.Materials...

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Bibliographic Details
Main Authors: Jiejie Hu, Lijun Qin, Guoqiang Zhu, Jingjing Ren, Hongxia Wang, Jing Jin, Haixue Zheng, Dan Li, Zhaoming Ge
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Genetics
Subjects:
ferroptosis
ischemia/reperfusion
brain microvascular endothelial cells
SESN2
system Xc-
RNA-seq
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2024.1504114/full
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