Immunohistochemical Expression of Dual-Specificity Protein Phosphatase 4 in Patients with Colorectal Adenocarcinoma
The role of dual-specificity protein phosphatase 4 (DUSP4) appears to vary with the type of malignant tumors and is still controversial. The purpose of our study was to clarify the exact role of DUSP4 expression in colorectal adenocarcinoma. We constructed tissue microarrays and investigated DUSP4 e...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2015/283764 |
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| author | Jongmin Sim Kijong Yi Hyunsung Kim Hyein Ahn Yumin Chung Abdul Rehman Se Min Jang Kang Hong Lee Kiseok Jang Seung Sam Paik |
| author_facet | Jongmin Sim Kijong Yi Hyunsung Kim Hyein Ahn Yumin Chung Abdul Rehman Se Min Jang Kang Hong Lee Kiseok Jang Seung Sam Paik |
| author_sort | Jongmin Sim |
| collection | DOAJ |
| description | The role of dual-specificity protein phosphatase 4 (DUSP4) appears to vary with the type of malignant tumors and is still controversial. The purpose of our study was to clarify the exact role of DUSP4 expression in colorectal adenocarcinoma. We constructed tissue microarrays and investigated DUSP4 expression by immunohistochemistry. DUSP4 was more frequently expressed in adenocarcinomas and lymph node/distant metastases compared to that in normal colorectal tissues and tubular adenomas (P<0.001). Mean DUSP4 expression score was significantly higher in malignant tumors than in benign lesions (P<0.001). DUSP4 expression was significantly correlated with older age (P=0.017), male gender (P=0.036), larger tumor size (P=0.014), nonmucinous tumor type (P=0.023), and higher T stage (P=0.040). Kaplan-Meier survival curves revealed a significant effect of DUSP4 expression on both overall survival and disease-free survival in AJCC stage I (P=0.008 and P=0.003, resp., log-rank test) and male gender (P=0.017 and P=0.049, resp., log-rank test). DUSP4 protein is frequently upregulated in colorectal adenocarcinoma and may play an important role in carcinogenesis and cancer progression and may be a marker of adverse prognosis. |
| format | Article |
| id | doaj-art-e776c73d35e44ef08f7b59dcb3ebbf1a |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-e776c73d35e44ef08f7b59dcb3ebbf1a2025-02-03T01:12:28ZengWileyGastroenterology Research and Practice1687-61211687-630X2015-01-01201510.1155/2015/283764283764Immunohistochemical Expression of Dual-Specificity Protein Phosphatase 4 in Patients with Colorectal AdenocarcinomaJongmin Sim0Kijong Yi1Hyunsung Kim2Hyein Ahn3Yumin Chung4Abdul Rehman5Se Min Jang6Kang Hong Lee7Kiseok Jang8Seung Sam Paik9Department of Pathology, College of Medicine, Hanyang University, Seoul 133-792, Republic of KoreaDepartment of Pathology, College of Medicine, Hanyang University, Seoul 133-792, Republic of KoreaDepartment of Pathology, College of Medicine, Hanyang University, Seoul 133-792, Republic of KoreaDepartment of Pathology, College of Medicine, Hanyang University, Seoul 133-792, Republic of KoreaDepartment of Pathology, College of Medicine, Hanyang University, Seoul 133-792, Republic of KoreaDepartment of Pathology, College of Medicine, Hanyang University, Seoul 133-792, Republic of KoreaDepartment of Pathology, College of Medicine, Hanyang University, Seoul 133-792, Republic of KoreaDepartment of Surgery, College of Medicine, Hanyang University, Seoul 133-792, Republic of KoreaDepartment of Pathology, College of Medicine, Hanyang University, Seoul 133-792, Republic of KoreaDepartment of Pathology, College of Medicine, Hanyang University, Seoul 133-792, Republic of KoreaThe role of dual-specificity protein phosphatase 4 (DUSP4) appears to vary with the type of malignant tumors and is still controversial. The purpose of our study was to clarify the exact role of DUSP4 expression in colorectal adenocarcinoma. We constructed tissue microarrays and investigated DUSP4 expression by immunohistochemistry. DUSP4 was more frequently expressed in adenocarcinomas and lymph node/distant metastases compared to that in normal colorectal tissues and tubular adenomas (P<0.001). Mean DUSP4 expression score was significantly higher in malignant tumors than in benign lesions (P<0.001). DUSP4 expression was significantly correlated with older age (P=0.017), male gender (P=0.036), larger tumor size (P=0.014), nonmucinous tumor type (P=0.023), and higher T stage (P=0.040). Kaplan-Meier survival curves revealed a significant effect of DUSP4 expression on both overall survival and disease-free survival in AJCC stage I (P=0.008 and P=0.003, resp., log-rank test) and male gender (P=0.017 and P=0.049, resp., log-rank test). DUSP4 protein is frequently upregulated in colorectal adenocarcinoma and may play an important role in carcinogenesis and cancer progression and may be a marker of adverse prognosis.http://dx.doi.org/10.1155/2015/283764 |
| spellingShingle | Jongmin Sim Kijong Yi Hyunsung Kim Hyein Ahn Yumin Chung Abdul Rehman Se Min Jang Kang Hong Lee Kiseok Jang Seung Sam Paik Immunohistochemical Expression of Dual-Specificity Protein Phosphatase 4 in Patients with Colorectal Adenocarcinoma Gastroenterology Research and Practice |
| title | Immunohistochemical Expression of Dual-Specificity Protein Phosphatase 4 in Patients with Colorectal Adenocarcinoma |
| title_full | Immunohistochemical Expression of Dual-Specificity Protein Phosphatase 4 in Patients with Colorectal Adenocarcinoma |
| title_fullStr | Immunohistochemical Expression of Dual-Specificity Protein Phosphatase 4 in Patients with Colorectal Adenocarcinoma |
| title_full_unstemmed | Immunohistochemical Expression of Dual-Specificity Protein Phosphatase 4 in Patients with Colorectal Adenocarcinoma |
| title_short | Immunohistochemical Expression of Dual-Specificity Protein Phosphatase 4 in Patients with Colorectal Adenocarcinoma |
| title_sort | immunohistochemical expression of dual specificity protein phosphatase 4 in patients with colorectal adenocarcinoma |
| url | http://dx.doi.org/10.1155/2015/283764 |
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