An NTCP Analysis of Urethral Complications from Low Doserate Mono- and Bi-Radionuclide Brachytherapy
Urethral NTCP has been determined for three prostates implanted with seeds based on 125I (145 Gy), 103Pd (125 Gy), 131Cs (115 Gy), 103Pd-125I (145 Gy), or 103Pd-131Cs (115 Gy or 130 Gy). First, DU20, meaning that 20% of the urhral volume receive a dose of at least DU20, is converted into an I-125 LD...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Prostate Cancer |
| Online Access: | http://dx.doi.org/10.1155/2011/128360 |
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| author | V. E. Nuttens A. E. Nahum S. Lucas |
| author_facet | V. E. Nuttens A. E. Nahum S. Lucas |
| author_sort | V. E. Nuttens |
| collection | DOAJ |
| description | Urethral NTCP has been determined for three prostates implanted with seeds based on 125I (145 Gy), 103Pd (125 Gy), 131Cs (115 Gy), 103Pd-125I (145 Gy), or 103Pd-131Cs (115 Gy or 130 Gy).
First, DU20, meaning that 20% of the urhral volume receive a dose of at least DU20, is converted into an I-125 LDR equivalent DU20 in order to use the urethral NTCP model.
Second, the propagation of uncertainties through the steps in the NTCP calculation was assessed in order to identify the parameters responsible for large data uncertainties. Two sets of radiobiological parameters were studied. The NTCP results all fall in the 19%–23% range and are associated with large uncertainties, making the comparison difficult. Depending on the dataset chosen, the ranking of NTCP values among the six seed implants studied changes. Moreover, the large uncertainties on the fitting parameters of the urethral NTCP model result in large uncertainty on the NTCP value. In conclusion, the use of NTCP model for permanent brachytherapy is feasible but it is essential that the uncertainties on the parameters in the model be reduced. |
| format | Article |
| id | doaj-art-e76c103aa5ea43fd82eab61aa8b4b8df |
| institution | Kabale University |
| issn | 2090-3111 2090-312X |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Prostate Cancer |
| spelling | doaj-art-e76c103aa5ea43fd82eab61aa8b4b8df2025-02-03T07:24:49ZengWileyProstate Cancer2090-31112090-312X2011-01-01201110.1155/2011/128360128360An NTCP Analysis of Urethral Complications from Low Doserate Mono- and Bi-Radionuclide BrachytherapyV. E. Nuttens0A. E. Nahum1S. Lucas2NAmur Research Institute for LIfe Sciences (NARILIS), Research Center for the Physics of Matter and Radiation (PMR-LARN), University of Namur (FUNDP), Rue de Bruxelles, 61, 5000 Namur, BelgiumDepartment of Physics, Clatterbridge Center for Oncology, Clatterbridge Road Bebington, Merseyside CH63 4JY, UKNAmur Research Institute for LIfe Sciences (NARILIS), Research Center for the Physics of Matter and Radiation (PMR-LARN), University of Namur (FUNDP), Rue de Bruxelles, 61, 5000 Namur, BelgiumUrethral NTCP has been determined for three prostates implanted with seeds based on 125I (145 Gy), 103Pd (125 Gy), 131Cs (115 Gy), 103Pd-125I (145 Gy), or 103Pd-131Cs (115 Gy or 130 Gy). First, DU20, meaning that 20% of the urhral volume receive a dose of at least DU20, is converted into an I-125 LDR equivalent DU20 in order to use the urethral NTCP model. Second, the propagation of uncertainties through the steps in the NTCP calculation was assessed in order to identify the parameters responsible for large data uncertainties. Two sets of radiobiological parameters were studied. The NTCP results all fall in the 19%–23% range and are associated with large uncertainties, making the comparison difficult. Depending on the dataset chosen, the ranking of NTCP values among the six seed implants studied changes. Moreover, the large uncertainties on the fitting parameters of the urethral NTCP model result in large uncertainty on the NTCP value. In conclusion, the use of NTCP model for permanent brachytherapy is feasible but it is essential that the uncertainties on the parameters in the model be reduced.http://dx.doi.org/10.1155/2011/128360 |
| spellingShingle | V. E. Nuttens A. E. Nahum S. Lucas An NTCP Analysis of Urethral Complications from Low Doserate Mono- and Bi-Radionuclide Brachytherapy Prostate Cancer |
| title | An NTCP Analysis of Urethral Complications from Low Doserate Mono- and Bi-Radionuclide Brachytherapy |
| title_full | An NTCP Analysis of Urethral Complications from Low Doserate Mono- and Bi-Radionuclide Brachytherapy |
| title_fullStr | An NTCP Analysis of Urethral Complications from Low Doserate Mono- and Bi-Radionuclide Brachytherapy |
| title_full_unstemmed | An NTCP Analysis of Urethral Complications from Low Doserate Mono- and Bi-Radionuclide Brachytherapy |
| title_short | An NTCP Analysis of Urethral Complications from Low Doserate Mono- and Bi-Radionuclide Brachytherapy |
| title_sort | ntcp analysis of urethral complications from low doserate mono and bi radionuclide brachytherapy |
| url | http://dx.doi.org/10.1155/2011/128360 |
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