Stem Cell-Based Therapeutic Approaches to Restore Sensorineural Hearing Loss in Mammals
The hair cells that reside in the cochlear sensory epithelium are the fundamental sensory structures responsible for understanding the mechanical sound waves evoked in the environment. The intense damage to these sensory structures may result in permanent hearing loss. The present strategies to reha...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2020/8829660 |
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| author | Muhammad Waqas Iram Us-Salam Zainab Bibi Yunfeng Wang He Li Zhongshou Zhu Shuangba He |
| author_facet | Muhammad Waqas Iram Us-Salam Zainab Bibi Yunfeng Wang He Li Zhongshou Zhu Shuangba He |
| author_sort | Muhammad Waqas |
| collection | DOAJ |
| description | The hair cells that reside in the cochlear sensory epithelium are the fundamental sensory structures responsible for understanding the mechanical sound waves evoked in the environment. The intense damage to these sensory structures may result in permanent hearing loss. The present strategies to rehabilitate the hearing function include either hearing aids or cochlear implants that may recover the hearing capability of deaf patients to a limited extent. Therefore, much attention has been paid on developing regenerative therapies to regenerate/replace the lost hair cells to treat the damaged cochlear sensory epithelium. The stem cell therapy is a promising approach to develop the functional hair cells and neuronal cells from endogenous and exogenous stem cell pool to recover hearing loss. In this review, we specifically discuss the potential of different kinds of stem cells that hold the potential to restore sensorineural hearing loss in mammals and comprehensively explain the current therapeutic applications of stem cells in both the human and mouse inner ear to regenerate/replace the lost hair cells and spiral ganglion neurons. |
| format | Article |
| id | doaj-art-e755e25b4c584a0da47ba75685dd062c |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-e755e25b4c584a0da47ba75685dd062c2025-02-03T06:04:37ZengWileyNeural Plasticity2090-59041687-54432020-01-01202010.1155/2020/88296608829660Stem Cell-Based Therapeutic Approaches to Restore Sensorineural Hearing Loss in MammalsMuhammad Waqas0Iram Us-Salam1Zainab Bibi2Yunfeng Wang3He Li4Zhongshou Zhu5Shuangba He6Department of Biotechnology, Federal Urdu University of Arts, Science and Technology, Gulshan-e-Iqbal Campus, Karachi, PakistanDepartment of Biotechnology, Federal Urdu University of Arts, Science and Technology, Gulshan-e-Iqbal Campus, Karachi, PakistanDepartment of Biotechnology, Federal Urdu University of Arts, Science and Technology, Gulshan-e-Iqbal Campus, Karachi, PakistanENT Institute and Otorhinolaryngology Department of Eye & ENT Hospital, Fudan University, Shanghai 200031, ChinaDepartment of Otolaryngology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou City, 325000 Zhejiang Province, ChinaDepartment of Otolaryngology, Ningde Municipal Hospital Affiliated of Fujian Medical University (Ningde Institute of Otolaryngology), Ningde, Fujian 352100, ChinaDepartment of Otolaryngology Head and Neck, Nanjing Tongren Hospital, School of Medicine, Southeast University, Nanjing 211102, ChinaThe hair cells that reside in the cochlear sensory epithelium are the fundamental sensory structures responsible for understanding the mechanical sound waves evoked in the environment. The intense damage to these sensory structures may result in permanent hearing loss. The present strategies to rehabilitate the hearing function include either hearing aids or cochlear implants that may recover the hearing capability of deaf patients to a limited extent. Therefore, much attention has been paid on developing regenerative therapies to regenerate/replace the lost hair cells to treat the damaged cochlear sensory epithelium. The stem cell therapy is a promising approach to develop the functional hair cells and neuronal cells from endogenous and exogenous stem cell pool to recover hearing loss. In this review, we specifically discuss the potential of different kinds of stem cells that hold the potential to restore sensorineural hearing loss in mammals and comprehensively explain the current therapeutic applications of stem cells in both the human and mouse inner ear to regenerate/replace the lost hair cells and spiral ganglion neurons.http://dx.doi.org/10.1155/2020/8829660 |
| spellingShingle | Muhammad Waqas Iram Us-Salam Zainab Bibi Yunfeng Wang He Li Zhongshou Zhu Shuangba He Stem Cell-Based Therapeutic Approaches to Restore Sensorineural Hearing Loss in Mammals Neural Plasticity |
| title | Stem Cell-Based Therapeutic Approaches to Restore Sensorineural Hearing Loss in Mammals |
| title_full | Stem Cell-Based Therapeutic Approaches to Restore Sensorineural Hearing Loss in Mammals |
| title_fullStr | Stem Cell-Based Therapeutic Approaches to Restore Sensorineural Hearing Loss in Mammals |
| title_full_unstemmed | Stem Cell-Based Therapeutic Approaches to Restore Sensorineural Hearing Loss in Mammals |
| title_short | Stem Cell-Based Therapeutic Approaches to Restore Sensorineural Hearing Loss in Mammals |
| title_sort | stem cell based therapeutic approaches to restore sensorineural hearing loss in mammals |
| url | http://dx.doi.org/10.1155/2020/8829660 |
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