Predicting Low-Risk Prostate Cancer from Transperineal Saturation Biopsies
Introduction. To assess the performance of five previously described clinicopathological definitions of low-risk prostate cancer (PC). Materials and Methods. Men who underwent radical prostatectomy (RP) for clinical stage ≤T2, PSA <10 ng/mL, Gleason score <8 PC, diagnosed by transperineal temp...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Prostate Cancer |
| Online Access: | http://dx.doi.org/10.1155/2016/7105678 |
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| author | Pim J. van Leeuwen Amila Siriwardana Monique Roobol Francis Ting Daan Nieboer James Thompson Warick Delprado Anne-Marie Haynes Phillip Brenner Phillip Stricker |
| author_facet | Pim J. van Leeuwen Amila Siriwardana Monique Roobol Francis Ting Daan Nieboer James Thompson Warick Delprado Anne-Marie Haynes Phillip Brenner Phillip Stricker |
| author_sort | Pim J. van Leeuwen |
| collection | DOAJ |
| description | Introduction. To assess the performance of five previously described clinicopathological definitions of low-risk prostate cancer (PC). Materials and Methods. Men who underwent radical prostatectomy (RP) for clinical stage ≤T2, PSA <10 ng/mL, Gleason score <8 PC, diagnosed by transperineal template-guided saturation biopsy were included. The performance of five previously described criteria (i.e., criteria 1–5, criterion 1 stringent (Gleason score 6 + ≤5 mm total max core length PC + ≤3 mm max per core length PC) up to criterion 5 less stringent (Gleason score 6-7 with ≤5% Gleason grade 4) was analysed to assess ability of each to predict insignificant disease in RP specimens (defined as Gleason score ≤6 and total tumour volume <2.5 mL, or Gleason score 7 with ≤5% grade 4 and total tumour volume <0.7 mL). Results. 994 men who underwent RP were included. Criterion 4 (Gleason score 6) performed best with area under the curve of receiver operating characteristics 0.792. At decision curve analysis, criterion 4 was deemed clinically the best performing transperineal saturation biopsy-based definition for low-risk PC. Conclusions. Gleason score 6 disease demonstrated a superior trade-off between sensitivity and specificity for clarifying low-risk PC that can guide treatment and be used as reference test in diagnostic studies. |
| format | Article |
| id | doaj-art-e73c8a19430e4d4fba2c7e8a95499ed3 |
| institution | Kabale University |
| issn | 2090-3111 2090-312X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Prostate Cancer |
| spelling | doaj-art-e73c8a19430e4d4fba2c7e8a95499ed32025-02-03T06:13:56ZengWileyProstate Cancer2090-31112090-312X2016-01-01201610.1155/2016/71056787105678Predicting Low-Risk Prostate Cancer from Transperineal Saturation BiopsiesPim J. van Leeuwen0Amila Siriwardana1Monique Roobol2Francis Ting3Daan Nieboer4James Thompson5Warick Delprado6Anne-Marie Haynes7Phillip Brenner8Phillip Stricker9St Vincent’s Prostate Cancer Centre, St Vincent’s Clinic, Sydney, NSW 2010, AustraliaSt Vincent’s Prostate Cancer Centre, St Vincent’s Clinic, Sydney, NSW 2010, AustraliaDepartment of Urology, Erasmus University Medical Center, 3015 CE Rotterdam, NetherlandsSt Vincent’s Prostate Cancer Centre, St Vincent’s Clinic, Sydney, NSW 2010, AustraliaDepartment of Public Health, Erasmus University Medical Center, 3015 CE Rotterdam, NetherlandsSt Vincent’s Prostate Cancer Centre, St Vincent’s Clinic, Sydney, NSW 2010, AustraliaUniversity of Notre Dame, Sydney, NSW 2010, AustraliaAustralian Prostate Cancer Research Centre New South Wales, The Garvan Institute of Medical Research, The Kinghorn Cancer Centre, Sydney, NSW 2010, AustraliaSt Vincent’s Prostate Cancer Centre, St Vincent’s Clinic, Sydney, NSW 2010, AustraliaSt Vincent’s Prostate Cancer Centre, St Vincent’s Clinic, Sydney, NSW 2010, AustraliaIntroduction. To assess the performance of five previously described clinicopathological definitions of low-risk prostate cancer (PC). Materials and Methods. Men who underwent radical prostatectomy (RP) for clinical stage ≤T2, PSA <10 ng/mL, Gleason score <8 PC, diagnosed by transperineal template-guided saturation biopsy were included. The performance of five previously described criteria (i.e., criteria 1–5, criterion 1 stringent (Gleason score 6 + ≤5 mm total max core length PC + ≤3 mm max per core length PC) up to criterion 5 less stringent (Gleason score 6-7 with ≤5% Gleason grade 4) was analysed to assess ability of each to predict insignificant disease in RP specimens (defined as Gleason score ≤6 and total tumour volume <2.5 mL, or Gleason score 7 with ≤5% grade 4 and total tumour volume <0.7 mL). Results. 994 men who underwent RP were included. Criterion 4 (Gleason score 6) performed best with area under the curve of receiver operating characteristics 0.792. At decision curve analysis, criterion 4 was deemed clinically the best performing transperineal saturation biopsy-based definition for low-risk PC. Conclusions. Gleason score 6 disease demonstrated a superior trade-off between sensitivity and specificity for clarifying low-risk PC that can guide treatment and be used as reference test in diagnostic studies.http://dx.doi.org/10.1155/2016/7105678 |
| spellingShingle | Pim J. van Leeuwen Amila Siriwardana Monique Roobol Francis Ting Daan Nieboer James Thompson Warick Delprado Anne-Marie Haynes Phillip Brenner Phillip Stricker Predicting Low-Risk Prostate Cancer from Transperineal Saturation Biopsies Prostate Cancer |
| title | Predicting Low-Risk Prostate Cancer from Transperineal Saturation Biopsies |
| title_full | Predicting Low-Risk Prostate Cancer from Transperineal Saturation Biopsies |
| title_fullStr | Predicting Low-Risk Prostate Cancer from Transperineal Saturation Biopsies |
| title_full_unstemmed | Predicting Low-Risk Prostate Cancer from Transperineal Saturation Biopsies |
| title_short | Predicting Low-Risk Prostate Cancer from Transperineal Saturation Biopsies |
| title_sort | predicting low risk prostate cancer from transperineal saturation biopsies |
| url | http://dx.doi.org/10.1155/2016/7105678 |
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