Unveiling the antiglioblastoma potential of harmicens, harmine and ferrocene hybrids

Unveiling the antiglioblastoma potential of harmicens, harmine and ferrocene hybrids

The poor prognosis of glioblastoma multiforme, inadequate treatment options, and growing drug resistance urge the need to find new effective agents. Due to the significant anti-cancer potential of harmicens, hybrid compounds which comprise harmine/β-carboline and ferrocene moiety, we investigated th...

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Main Authors: Poje Goran, Šakić Davor, Marinović Marina, You Jiangyang, Tarpley Michael, Williams Kevin P., Golub Nikolina, Dernovšek Jaka, Tomašič Tihomir, Bešić Erim, Rajić Zrinka
Format: Article
Language:English
Published: Sciendo 2024-12-01
Series:Acta Pharmaceutica
Subjects:
harmine
β-carboline
ferrocene
hybrid compounds
antiproliferative activity
glioblastoma multiforme
hsp90
dyrk1a
antioxidant activity
epr spectroscopy
Online Access:https://doi.org/10.2478/acph-2024-0033
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https://doi.org/10.2478/acph-2024-0033

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