The impact of signaling pathways on the desmosome ultrastructure in pemphigus

The impact of signaling pathways on the desmosome ultrastructure in pemphigus

IntroductionThe autoantibody-driven disease pemphigus vulgaris (PV) impairs desmosome adhesion in the epidermis. In desmosomes, the pemphigus autoantigens desmoglein 1 (Dsg1) and Dsg3 link adjacent cells. Dsgs are clustered by plaque proteins and linked to the keratin cytoskeleton by desmoplakin (Dp...

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Bibliographic Details
Main Authors: Thomas Schmitt, Julia Huber, Julia Pircher, Enno Schmidt, Jens Waschke
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
adhesion
desmosomes
pemphigus
autoantibodies
autoimmune disease
skin
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1497241/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1497241/full

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