Biomimetic bioreactor for potentiated uricase replacement therapy in hyperuricemia and gout

Biomimetic bioreactor for potentiated uricase replacement therapy in hyperuricemia and gout

IntroductionUricase replacement therapy is a promising approach for managing hyperuricemia and gout but is hindered by challenges such as short blood circulation time, reduced catalytic activity, and excessive hydrogen peroxide (H2O2) production. These limitations necessitate innovative strategies t...

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Main Authors: Bin Yang, Guihu Luo, Tailei Nie, Zhenglan Ban, Quanxin Ning, Jialin Zhang, Xiangru Liu, Yanhua Lin, Xiaochun Xie, Qianyun Chen, Han Zhong, Ying Huang, Pan Liao, Yan Liu, Chenyang Guo, Chuanxu Cheng, Erwei Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
uricase
red blood cell coating
biomimetic bioreactor
selenium-based nanoscavenger
hyperuricemia
gout
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2024.1520663/full
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https://www.frontiersin.org/articles/10.3389/fbioe.2024.1520663/full

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