Overweight or Obese Individuals at Eighteen Years of Age Develop Pancreatic Adenocarcinoma at a Significantly Earlier Age
Background. Adolescent obesity is a national epidemic that recently has been shown to increase risk for pancreatic adenocarcinoma (PC) and is associated with an earlier age of PC onset. We hypothesized that PC patients who are overweight or obese at age 18 would have an earlier age of PC onset. Meth...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2018/2380596 |
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| author | David T. Chao Nilesh H. Shah Herbert J. Zeh Aatur D. Singhi Nathan Bahary Kevin M. McGrath Kenneth E. Fasanella Amer H. Zureikat David C. Whitcomb Randall E. Brand |
| author_facet | David T. Chao Nilesh H. Shah Herbert J. Zeh Aatur D. Singhi Nathan Bahary Kevin M. McGrath Kenneth E. Fasanella Amer H. Zureikat David C. Whitcomb Randall E. Brand |
| author_sort | David T. Chao |
| collection | DOAJ |
| description | Background. Adolescent obesity is a national epidemic that recently has been shown to increase risk for pancreatic adenocarcinoma (PC) and is associated with an earlier age of PC onset. We hypothesized that PC patients who are overweight or obese at age 18 would have an earlier age of PC onset. Methods. Retrospective review of 531 patients in our PC registry was completed. Self-reported weight at age 18 and maximum lifetime weight were used to calculate body mass index (BMI) at age 18 (BMI-18) and maximum lifetime BMI. Results. Complete BMI and baseline covariate data was available in 319 PC patients. Mean age (in years) of PC diagnosis for patients whose BMI-18 was overweight (64.0) or obese (59.9) was significantly different when compared to patients with a normal BMI-18 (66.7). No significant difference was observed in the mean age of PC diagnosis in those patients who maintained a normal BMI-18 when compared to those patients who subsequently became overweight or obese (67.0 versus 66.6; p=0.65). Conclusions. An elevated BMI at age 18 is associated with an earlier age of PC onset and should be factored into determining the optimal age of beginning screening for patients at high risk for PC. |
| format | Article |
| id | doaj-art-e7071c46e6964b80ae8b5771e7bddb2c |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-e7071c46e6964b80ae8b5771e7bddb2c2025-02-03T01:20:03ZengWileyGastroenterology Research and Practice1687-61211687-630X2018-01-01201810.1155/2018/23805962380596Overweight or Obese Individuals at Eighteen Years of Age Develop Pancreatic Adenocarcinoma at a Significantly Earlier AgeDavid T. Chao0Nilesh H. Shah1Herbert J. Zeh2Aatur D. Singhi3Nathan Bahary4Kevin M. McGrath5Kenneth E. Fasanella6Amer H. Zureikat7David C. Whitcomb8Randall E. Brand9Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USADepartment of Dental Public Health, University of Pittsburgh, Pittsburgh, PA, USADivision of Gastrointestinal Surgical Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USADepartment of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USADivision of Hematology/Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USADepartment of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USADepartment of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USADivision of Gastrointestinal Surgical Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USADepartment of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USADepartment of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USABackground. Adolescent obesity is a national epidemic that recently has been shown to increase risk for pancreatic adenocarcinoma (PC) and is associated with an earlier age of PC onset. We hypothesized that PC patients who are overweight or obese at age 18 would have an earlier age of PC onset. Methods. Retrospective review of 531 patients in our PC registry was completed. Self-reported weight at age 18 and maximum lifetime weight were used to calculate body mass index (BMI) at age 18 (BMI-18) and maximum lifetime BMI. Results. Complete BMI and baseline covariate data was available in 319 PC patients. Mean age (in years) of PC diagnosis for patients whose BMI-18 was overweight (64.0) or obese (59.9) was significantly different when compared to patients with a normal BMI-18 (66.7). No significant difference was observed in the mean age of PC diagnosis in those patients who maintained a normal BMI-18 when compared to those patients who subsequently became overweight or obese (67.0 versus 66.6; p=0.65). Conclusions. An elevated BMI at age 18 is associated with an earlier age of PC onset and should be factored into determining the optimal age of beginning screening for patients at high risk for PC.http://dx.doi.org/10.1155/2018/2380596 |
| spellingShingle | David T. Chao Nilesh H. Shah Herbert J. Zeh Aatur D. Singhi Nathan Bahary Kevin M. McGrath Kenneth E. Fasanella Amer H. Zureikat David C. Whitcomb Randall E. Brand Overweight or Obese Individuals at Eighteen Years of Age Develop Pancreatic Adenocarcinoma at a Significantly Earlier Age Gastroenterology Research and Practice |
| title | Overweight or Obese Individuals at Eighteen Years of Age Develop Pancreatic Adenocarcinoma at a Significantly Earlier Age |
| title_full | Overweight or Obese Individuals at Eighteen Years of Age Develop Pancreatic Adenocarcinoma at a Significantly Earlier Age |
| title_fullStr | Overweight or Obese Individuals at Eighteen Years of Age Develop Pancreatic Adenocarcinoma at a Significantly Earlier Age |
| title_full_unstemmed | Overweight or Obese Individuals at Eighteen Years of Age Develop Pancreatic Adenocarcinoma at a Significantly Earlier Age |
| title_short | Overweight or Obese Individuals at Eighteen Years of Age Develop Pancreatic Adenocarcinoma at a Significantly Earlier Age |
| title_sort | overweight or obese individuals at eighteen years of age develop pancreatic adenocarcinoma at a significantly earlier age |
| url | http://dx.doi.org/10.1155/2018/2380596 |
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