The structure of an amyloid precursor protein/talin complex indicates a mechanical basis of Alzheimer’s disease

The structure of an amyloid precursor protein/talin complex indicates a mechanical basis of Alzheimer’s disease

Misprocessing of amyloid precursor protein (APP) is one of the major causes of Alzheimer’s disease. APP comprises a large extracellular region, a single transmembrane helix and a short cytoplasmic tail containing an NPxY motif (normally referred to as the YENPTY motif). Talins are synaptic scaffold...

Full description

Saved in:
Bibliographic Details
Main Authors: Charles Ellis, Natasha L. Ward, Matthew Rice, Neil J. Ball, Pauline Walle, Chloé Najdek, Devrim Kilinc, Jean-Charles Lambert, Julien Chapuis, Benjamin T. Goult
Format: Article
Language:English
Published: The Royal Society 2024-11-01
Series:Open Biology
Subjects:
Alzheimer’s disease
TLN1
meshCODE
amyloid precursor protein
dementia
FERMT2
Online Access:https://royalsocietypublishing.org/doi/10.1098/rsob.240185
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://royalsocietypublishing.org/doi/10.1098/rsob.240185

Similar Items